Sensory information from nociceptors and touch receptors, such as Aβ-fiber
mechanoreceptors and C-fiber low-threshold mechanoreceptors (C-LTMRs), is normally …

Neuropathic pain is characterized by mechanical allodynia induced by low-threshold
myelinated Aβ-fiber activation. The original gate theory of pain proposes that inhibitory …

Central sensitization in inflammatory pain conditions results in behavioral mechanical
hypersensitivity. Specifically, C-fiber-driven spinal hyperexcitability enables A fibers to gain …

Psychophysical and fMRI findings suggest reduced C-tactile mediated hedonic processing
in tactile allodynia. However, Aβ signaling is required for the perception of allodynic pain …

The sensation of touch is initiated when fast conducting low-threshold mechanoreceptors
(Aβ-LTMRs) generate impulses at their terminals in the skin. Plasticity in this system is …

Abstract Recently, Cervero and Laird (NeuroReport, 7 (1996) 526–528; Pain, 68 (1996) 13–
23) proposed a new pathophysiological mechanism of dynamic mechanical allodynia in …

Chronic pain presents a major unmet clinical problem. The development of more effective
treatments is hindered by our limited understanding of the neuronal circuits underlying …

Background Causes of neuropathic pain following nerve injury remain unclear, limiting the
development of mechanism-based therapeutic approaches. Animal models have provided …

Mechanical hypersensitivity is a debilitating symptom for millions of chronic pain patients. It
exists in distinct forms, including brush-evoked dynamic and filament-evoked punctate …

Mechanical allodynia is a cardinal feature of pathological pain. Recent work has
demonstrated the necessity of Aβ-low-threshold mechanoreceptors (Aβ-LTMRs) for …