Engulfment and subsequent degradation of apoptotic cells is an essential step that occurs
throughout life in all multicellular organisms,,. ELMO/Dock180/Rac proteins are a conserved …

Apoptosis and the subsequent clearance of dying cells occurs throughout development and
adult life in many tissues. Failure to promptly clear apoptotic cells has been linked to many …

Integrin receptors are important for the phagocytosis of apoptotic cells. However, little is
known about their function in mediating internalization, as previous studies used blocking …

Background: Phagocytosis of cells undergoing apoptosis is essential during development,
cellular turnover, and wound healing. Failure to promptly clear apoptotic cells has been …

Programmed cell death is critical both for organ formation during development and during
adult life, when billions of cells must be removed every day. The culmination of the apoptotic …

Dock180 superfamily of proteins has been recently identified as novel, unconventional
guanine nucleotide exchange factors (GEF) for Rho‐family GTPases. Unlike most other …

Apoptotic cell death is essential for development and tissue homeostasis [1, 2]. Failure to
clear apoptotic cells can ultimately cause inflammation and autoimmunity [3, 4]. Apoptosis …

Engulfment of apoptotic cells occurs throughout life in multicellular organisms. Impaired
apoptotic cell clearance (due to defective recognition, internalization or degradation) results …

Engulfment of apoptotic cells is an active process coordinated by receptors on phagocytes
and ligands on apoptotic cells [1]. Phosphatidylserine (PtdSer) is a key ligand on apoptotic …

* Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, 13288 Marseille
Cedex 09, France† Department of Biology, Amherst College, Amherst, Massachussetts …