Recurrent pregnancy loss (RPL) is a common and severe pathological pregnancy, whose
pathogenesis is not fully understood. With the development of epigenetics, the study of DNA …

Background Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms
are not completely understood. DNA methylation, which includes maintenance methylation …

Critical roles for DNA methylation in embryonic development are well established, but less is
known about its roles during trophoblast development, the extraembryonic lineage that gives …

Epigenetic modifications, and particularly DNA methylation, have been studied in many
tissues, both healthy and diseased, and across numerous developmental stages. The …

Multiple environmental, behavioral, and hereditary factors affect pregnancy. Recent studies
suggest that epigenetic modifications, such as DNA methylation (DNAm), affect both …

Epigenetics modification such as DNA methylation can affect maternal health during the
gestation period. Furthermore, pregnancy can drive a range of physiological and molecular …

Background Aberrant DNA methylation is considered to be a potential cause of recurrent
pregnancy loss (RPL), while potential mechanism has not yet been elucidated. Methods In …

Environmental BaP (benzo (a) pyrene) and its metabolite BPDE (benzo (a) pyrene-7, 8-
dihydrodiol-9, 10-epoxide) inhibit proliferation of human villous trophoblast cells, which …

During pregnancy, the maternal immune system undergoes major adaptive modifications
that are necessary for the acceptance and protection of the fetus. It has been postulated that …

Immune function in the vagina of hen oviduct is essential to prevent infection by
microorganisms colonizing in the cloaca. The aim of this study was to determine whether …