The chemokine receptor CXCR3 promotes the trafficking of activated T and NK cells in
response to three ligands, CXCL9, CXCL10, and CXCL11. Although these chemokines are …

Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In
this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T …

Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1 T cell-mediated disease
of the CNS, used to study certain aspects of multiple sclerosis. CXCR3, the receptor for …

The inflammatory response in the CNS begins with the movement of leukocytes across the
blood-brain barrier in a multistep process that requires cells to pass through a perivascular …

Experimental autoimmune encephalomyelitis (EAE) is a Tcell-mediated autoimmune
disease of the CNS that is widely used as an animal model of multiple sclerosis. In this …

The chemokines CXCL9 and CXCL10 bind to the common receptor CXCR3 and are
implicated in the pathogenesis of T‐cell‐mediated immunity in the central nervous system …

Cases of progressive multifocal leukoencephalopathy can occur in patients treated with the
B cell depleting anti-CD20 antibody, rituximab, highlighting the importance of B cell …

A single G protein–coupled receptor (GPCR) can activate multiple signaling cascades
based on the binding of different ligands. The biological relevance of this feature in immune …

Intracerebral infection of mice with mouse hepatitis virus (MHV) results in an acute
encephalomyelitis followed by a chronic demyelinating disease with clinical and histological …

T-cell accumulation in the central nervous system (CNS) is considered crucial to the
pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the …