CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis

BT Fife, GB Huffnagle, WA Kuziel… - The Journal of …, 2000 - rupress.org
Experimental autoimmune encephalomyelitis (EAE) is a CD4+ T lymphocyte–mediated
disease of the central nervous system (CNS) characterized by mononuclear cell infiltration …

Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis

A Elhofy, RW DePaolo, SA Lira, NW Lukacs… - Journal of …, 2009 - Elsevier
Chemokines are a superfamily of chemotactic cytokines that play an important role in
leukocyte trafficking and have been implicated as functional mediators of immunopathology …

Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice

C De Lemos, JE Christensen, A Nansen… - The Journal of …, 2005 - journals.aai.org
T cells play a key role in the control of viral infection in the CNS but may also contribute to
immune-mediated cell damage. To study the redundancy of the chemokine receptors …

Regulation of neuroinflammation: the role of CXCL10 in lymphocyte infiltration during autoimmune encephalomyelitis

RS Klein - Journal of cellular biochemistry, 2004 - Wiley Online Library
The movement of lymphocytes from the microvasculature into the central nervous system
(CNS) parenchyma is an essential step in the pathogenesis of a variety of infectious and …

Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis

A Ridderstad Wollberg… - Proceedings of the …, 2014 - National Acad Sciences
One hallmark of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis
(EAE) is infiltration of leukocytes into the CNS, where chemokines and their receptors play a …

CXCL10 (IFN-γ-inducible protein-10) control of encephalitogenic CD4+ T cell accumulation in the central nervous system during experimental autoimmune …

BT Fife, KJ Kennedy, MC Paniagua… - The Journal of …, 2001 - journals.aai.org
Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1-mediated demyelinating
disease of the CNS that serves as a model for multiple sclerosis. A critical event in the …

Production of CCL2 by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF …

RNE Dogan, A Elhofy, WJ Karpus - The Journal of Immunology, 2008 - journals.aai.org
Experimental autoimmune encephalomyelitis is a T cell-mediated demyelinating disease of
the CNS that serves as a model for the human disease multiple sclerosis. Increased …

Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

YM Khaw, C Cunningham, A Tierney… - Journal of …, 2020 - Springer
Background Multiple sclerosis (MS) is a chronic debilitating immune-mediated disease of
the central nervous system (CNS) driven by demyelination and gray matter …

CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous …

JE Christensen, C De Lemos, T Moos… - The Journal of …, 2006 - journals.aai.org
Abstract IFN-γ-inducible protein 10/CXCL10 is a chemokine associated with type 1 T cell
responses, regulating the migration of activated T cells through binding to the CXCR3 …

Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: implications for the …

S Columba‐Cabezas, BS Elena, AF Aloisi - Brain pathology, 2003 - Wiley Online Library
The simultaneous presence of dendritic, T‐and B‐cells in the central nervous system (CNS)
of mice with experimental autoimmune encephalomyelitis (EAE), a model for multiple …