[HTML][HTML] Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer development

T Zhang, H Zhou, K Wang, X Wang, M Wang… - Biomedicine & …, 2022 - Elsevier
Breast cancer (BC) is one of the most common malignant tumors in women globally, and its
occurrence has surpassed lung cancer and become the biggest threat for women. At …

[HTML][HTML] Breast cancer stem cells

JS Crabtree, L Miele - Biomedicines, 2018 - mdpi.com
Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression,
metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain …

[HTML][HTML] Breast cancer stem cells: Signaling pathways, cellular interactions, and therapeutic implications

L Wang, Z Jin, RP Master, CK Maharjan, ME Carelock… - Cancers, 2022 - mdpi.com
Simple Summary Cancer stem cells (CSCs) in breast cancer have been identified for almost
two decades. Many outstanding discoveries have established the important functions of …

[HTML][HTML] Signaling pathways governing the maintenance of breast cancer stem cells and their therapeutic implications

A Ordaz-Ramos, O Tellez-Jimenez… - Frontiers in cell and …, 2023 - frontiersin.org
Breast cancer stem cells (BCSCs) represent a distinct subpopulation of cells with the ability
to self-renewal and differentiate into phenotypically diverse tumor cells. The involvement of …

Cancer stem cell in breast cancer therapeutic resistance

X Bai, J Ni, J Beretov, P Graham, Y Li - Cancer treatment reviews, 2018 - Elsevier
Abstract Development of therapeutic resistance and metastasis is a major challenge with
current breast cancer (BC) therapy. Mounting evidence suggests that a subpopulation of …

[HTML][HTML] Mechanistic pathways of malignancy in breast cancer stem cells

S Yousefnia, F Seyed Forootan… - Frontiers in …, 2020 - frontiersin.org
Breast cancer stem cells (BCSCs) are the minor population of breast cancer (BC) cells that
exhibit several phenotypes such as migration, invasion, self-renewal, and chemotherapy as …

Recent developments in targeting breast cancer stem cells (BCSCs): a descriptive review of therapeutic strategies and emerging therapies

K Ali, M Nabeel, F Mohsin, M Iqtedar, M Islam… - Medical Oncology, 2024 - Springer
Despite recent advancements in the diagnosis and treatment of breast cancer (BC), patient
outcomes in terms of survival, recurrence, and disease progression remain suboptimal. A …

Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications

X Zeng, C Liu, J Yao, H Wan, G Wan, Y Li… - Pharmacological …, 2021 - Elsevier
Both hereditary and sporadic breast cancer are suggested to develop from a stem cell
subcomponent retaining most key stem cell properties but with dysregulation of self-renewal …

Targeting cellular signaling pathways in breast cancer stem cells and its implication for cancer treatment

BRB Pires, ÍSS DE AMORIM, LDE Souza… - Anticancer …, 2016 - ar.iiarjournals.org
Breast cancer is a public health problem both in developing and developed countries. The
breast cancer stem cell (BCSC) hypothesis has grown in the cancer research community …

[HTML][HTML] Breast cancer stem cells: biomarkers, identification and isolation methods, regulating mechanisms, cellular origin, and beyond

X Zhang, K Powell, L Li - Cancers, 2020 - mdpi.com
Simple Summary Breast cancer stem cells are blamed to be responsible for breast cancer
tumorigenesis, metastasis, drug resistance and tumor recurrence. Therefore, it is critical to …