Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature
osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the …

Abstract Chemokine CCL4 (MIP-1β) is released from osteoblast cells to restore the
homeostasis of hematopoietic stem cells during the activation of bone marrow. In this study …

The migration of osteoclasts (OCs) from circulation and bone marrow into bone surface
plays a critical role in the pathogenesis of some bone resorptive diseases, such as …

The receptor activator of nuclear factor-κB ligand (RANKL), as a member of the tumor
necrosis factor (TNF) family, plays an essential role in osteoclast differentiation and function …

Normal bone homeostasis, which is regulated by bone-resorbing osteoclasts and bone-
forming osteoblasts is perturbed by inflammation. In chronic inflammatory disease with …

Human monocyte chemoattractant protein‐1 (MCP‐1) in mice has two orthologs, MCP‐1
and MCP‐5. MCP‐1, which is highly expressed in osteoclasts rather than in osteoclast …

Reorganization of the podosome into the sealing zone is crucial for osteoclasts (OCLs) to
resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous …

Increasing evidence emphasizes the importance of chemokines and chemokine receptors
as regulators of bone remodeling. The C–C chemokine receptor 3 (CCR3) is dramatically …

Background Phosphorylation modification of BCL2 is involved in receptor activator of
nuclear factor-κB ligand (RANKL)-induced autophagy of osteoclast precursors (OCPs) and …

Human osteoclast formation from monocyte precursors under the action of RANKL was
suppressed by GM-CSF, with down regulation of critical osteoclast-related nuclear factors …