Centrosome clustering control in osteoclasts through CCR5-mediated signaling
JW Lee, IH Lee, H Watanabe, Y Liu, K Sawada… - Scientific reports, 2023 - nature.com
Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature
osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the …
osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the …
CCL4 enhances preosteoclast migration and its receptor CCR5 downregulation by RANKL promotes osteoclastogenesis
D Lee, KJ Shin, DW Kim, KA Yoon, YJ Choi… - Cell Death & …, 2018 - nature.com
Abstract Chemokine CCL4 (MIP-1β) is released from osteoblast cells to restore the
homeostasis of hematopoietic stem cells during the activation of bone marrow. In this study …
homeostasis of hematopoietic stem cells during the activation of bone marrow. In this study …
Osteoclast differentiation gene expression profiling reveals chemokine CCL4 mediates RANKL‐induced osteoclast migration and invasion via PI3K pathway
W Xuan, X Feng, C Qian, L Peng, Y Shi… - Cell Biochemistry …, 2017 - Wiley Online Library
The migration of osteoclasts (OCs) from circulation and bone marrow into bone surface
plays a critical role in the pathogenesis of some bone resorptive diseases, such as …
plays a critical role in the pathogenesis of some bone resorptive diseases, such as …
RANKL downregulates cell surface CXCR6 expression through JAK2/STAT3 signaling pathway during osteoclastogenesis
C Li, J Zhao, L Sun, Z Yao, R Liu, J Huang… - … and biophysical research …, 2012 - Elsevier
The receptor activator of nuclear factor-κB ligand (RANKL), as a member of the tumor
necrosis factor (TNF) family, plays an essential role in osteoclast differentiation and function …
necrosis factor (TNF) family, plays an essential role in osteoclast differentiation and function …
CCL11, a novel mediator of inflammatory bone resorption
E Kindstedt, CK Holm, R Sulniute… - Scientific reports, 2017 - nature.com
Normal bone homeostasis, which is regulated by bone-resorbing osteoclasts and bone-
forming osteoblasts is perturbed by inflammation. In chronic inflammatory disease with …
forming osteoblasts is perturbed by inflammation. In chronic inflammatory disease with …
MCP‐5 suppresses osteoclast differentiation through Ccr5 upregulation
JH Kim, K Kim, I Kim, S Seong… - Journal of Cellular …, 2024 - Wiley Online Library
Human monocyte chemoattractant protein‐1 (MCP‐1) in mice has two orthologs, MCP‐1
and MCP‐5. MCP‐1, which is highly expressed in osteoclasts rather than in osteoclast …
and MCP‐5. MCP‐1, which is highly expressed in osteoclasts rather than in osteoclast …
TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42
S Xu, Y Zhang, J Wang, K Li, K Tan, K Liang… - Cell Death & …, 2018 - nature.com
Reorganization of the podosome into the sealing zone is crucial for osteoclasts (OCLs) to
resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous …
resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous …
CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice
S Rosendahl, R Sulniute, M Eklund, CK Holm… - Journal of Biological …, 2021 - ASBMB
Increasing evidence emphasizes the importance of chemokines and chemokine receptors
as regulators of bone remodeling. The C–C chemokine receptor 3 (CCR3) is dramatically …
as regulators of bone remodeling. The C–C chemokine receptor 3 (CCR3) is dramatically …
Phosphorylation of BCL2 at the Ser70 site mediates RANKL-induced osteoclast precursor autophagy and osteoclastogenesis
D Ke, Y Yu, C Li, J Han, J Xu - Molecular medicine, 2022 - Springer
Background Phosphorylation modification of BCL2 is involved in receptor activator of
nuclear factor-κB ligand (RANKL)-induced autophagy of osteoclast precursors (OCPs) and …
nuclear factor-κB ligand (RANKL)-induced autophagy of osteoclast precursors (OCPs) and …
[PDF][PDF] MCP-1 is induced by RANKL, promotes human osteoclast fusion and rescues GM-CSF suppression of osteoclast formation
MS Kim, CJ Day, NA Morrison - J Biol Chem, 2005 - academia.edu
Human osteoclast formation from monocyte precursors under the action of RANKL was
suppressed by GM-CSF, with down regulation of critical osteoclast-related nuclear factors …
suppressed by GM-CSF, with down regulation of critical osteoclast-related nuclear factors …