What are white matter hyperintensities made of? Relevance to vascular cognitive impairment

JM Wardlaw, MC Valdés Hernández… - Journal of the …, 2015 - Am Heart Assoc
White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

White matter hyperintensities, cognitive impairment and dementia: an update

ND Prins, P Scheltens - Nature Reviews Neurology, 2015 - nature.com
White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …

[HTML][HTML] White matter disease as a biomarker for long-term cerebrovascular disease and dementia

A Chutinet, NS Rost - Current treatment options in cardiovascular …, 2014 - Springer
Opinion statement White matter disease is commonly detected on brain MRI of aging
individuals as white matter hyperintensities (WMH), or 'leukoaraiosis.” Over the years, it has …

Current concepts of analysis of cerebral white matter hyperintensities on magnetic resonance imaging

M Yoshita, E Fletcher, C DeCarli - Topics in Magnetic Resonance …, 2005 - journals.lww.com
Cerebrovascular disease is common and associated with cognitive deficits and increased
risk for dementia. Until recently, only limited attention has focused on advances in imaging …

[HTML][HTML] White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

J Alber, S Alladi, HJ Bae, DA Barton, LA Beckett… - Alzheimer's & Dementia …, 2019 - Elsevier
White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral …

The effect of white matter hyperintensities on cognition is mediated by cortical atrophy

B Rizvi, A Narkhede, BS Last, M Budge, G Tosto… - Neurobiology of …, 2018 - Elsevier
White matter hyperintensities (WMH) have been linked to cognitive dysfunction and
dementia, although the reasons are unclear. One possibility is that WMH promote …

Cerebral white matter hyperintensities on MRI: current concepts and therapeutic implications

B Ovbiagele, JL Saver - Cerebrovascular Diseases, 2006 - karger.com
Background: White matter hyperintensities (WMH) are commonly observed MRI
abnormalities in the elderly, which generally reflect covert vascular brain injury. WMH …

Pathological correlates of white matter hyperintensities on magnetic resonance imaging

YS Shim, DW Yang, CM Roe, MA Coats… - Dementia and geriatric …, 2015 - karger.com
Abstract Background/Aims: We investigated the histopathological correlates of white matter
hyperintensities (WMHs) in participants with Alzheimer's disease (AD) or cerebrovascular …

[HTML][HTML] White matter hyperintensities and normal-appearing white matter integrity in the aging brain

SM Maniega, MCV Hernández, JD Clayden… - Neurobiology of …, 2015 - Elsevier
White matter hyperintensities (WMH) of presumed vascular origin are a common finding in
brain magnetic resonance imaging of older individuals and contribute to cognitive and …

White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory

J Kynast, L Lampe, T Luck, S Frisch… - Journal of Cerebral …, 2018 - journals.sagepub.com
Age-related white matter hyperintensities (WMH) are a manifestation of white matter damage
seen on magnetic resonance imaging (MRI). They are related to vascular risk factors and …