Objective White matter hyperintensities (WMH) observed on neuroimaging of elderly
individuals are associated with cognitive decline and disability. However, the pathogenesis …

Background: The association of white matter hyperintensities (WMH) with age-related
vascular and neurodegenerative pathologies remains incompletely understood. Objective …

Introduction It is unclear whether white matter hyperintensities (WMHs), magnetic resonance
imaging markers of small-vessel cerebrovascular disease, promote neurodegeneration and …

Background and Purpose—We have previously reported that several “silent” infarcts found
on magnetic resonance imaging (MRI) were a risk factor for stroke. Several recent reports …

The targeted brain dysfunction that accompanies aging can have a devastating effect on
cognitive and intellectual abilities. A significant proportion of older adults experience …

Several potential vascular risk factors exist for the development and accumulation of
subcortical white matter disease in older people. We have reported that in older people …

Background: White matter hyperintensities (WMH) on magnetic resonance imaging (MRI)
have been postulated to be a core feature of Alzheimer's disease. Clinicopathological …

As the older adult segment of the population increases, Alzheimer's disease (AD) has
emerged as a significant public health epidemic. Over the past 3 decades, advances in the …

Background: White matter hyperintensities of presumed vascular origin (WMH) are a
common finding in elderly people and a growing social malady in the aging western …

Objective: White matter hyperintensities (WMH) are commonly seen on neuroimaging scans,
but their underlying histopathologic substrate is unclear. The aim of this work was to …