White matter in different regions evolves differently during progression to dementia

M Dadar, J Maranzano, S Ducharme, DL Collins… - Neurobiology of …, 2019 - Elsevier
White matter hyperintensities (WMHs) are common in individuals with mild cognitive
impairment (MCI) and Alzheimer's disease. Patients with MCI with high WMH volumes are …

Progression of cerebral white matter lesions—clinical and radiological considerations

C Enzinger, F Fazekas, S Ropele, R Schmidt - Journal of the neurological …, 2007 - Elsevier
More than half of all elderly have some degree of white matter lesions (WML) on MRI of the
brain. Until recently, the rate of progression of WML was unknown. Recent work within …

White matter hyperintensities and cognition in mild cognitive impairment and Alzheimer's disease: a domain-specific meta-analysis

E Van Den Berg, MI Geerlings… - Journal of …, 2018 - content.iospress.com
Background: White matter hyperintensities (WMHs) are related to cognitive dysfunction in
the general population. The clinical relevance of WMHs in patients with Alzheimer's disease …

White matter hyperintensities: relationship to amyloid and tau burden

J Graff-Radford, EM Arenaza-Urquijo, DS Knopman… - Brain, 2019 - academic.oup.com
Although white matter hyperintensities have traditionally been viewed as a marker of
vascular disease, recent pathology studies have found an association between white matter …

Magnetic resonance imaging signal hyperintensities in the deep and subcortical white matter: a comparative study between stroke patients and normal volunteers

R Schmidt, F Fazekas, G Kleinert… - Archives of …, 1992 - jamanetwork.com
• Mixed population studies suggest a relationship between deep and subcortical white
matter hyperintensities on magnetic resonance imaging and cerebrovascular disease. To …

Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology

AA Gouw, A Seewann, H Vrenken, WM Van Der Flier… - Brain, 2008 - academic.oup.com
White matter hyperintensities (WMH) are frequently seen on T2-weighted MRI scans of
elderly subjects with and without Alzheimer's disease. WMH are only weakly and …

Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study

S Haller, E Kövari, FR Herrmann, V Cuvinciuc… - Acta neuropathologica …, 2013 - Springer
Background White matter hyperintensities (WMH) lesions on T2/FLAIR brain MRI are
frequently seen in healthy elderly people. Whether these radiological lesions correspond to …

White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients

EJ Burton, RA Kenny, J O'Brien, S Stephens… - Stroke, 2004 - Am Heart Assoc
Background—The importance of white matter hyperintensities (WMH) for cognitive
performance in older stroke patients is largely unknown. We hypothesized that processing …

Imaging of white matter lesions

F Barkhof, P Scheltens - Cerebrovascular diseases, 2002 - karger.com
Magnetic resonance imaging (MRI) is very sensitive for the detection of white matter lesions
(WML), which occur even in normal ageing. Intrinsic WML should be separated from …

White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?

FA Provenzano, J Muraskin, G Tosto… - JAMA …, 2013 - jamanetwork.com
Importance Current hypothetical models emphasize the importance of β-amyloid in
Alzheimer disease (AD) pathogenesis, although amyloid alone is not sufficient to account for …