Over the past 20 years, our understanding of the molecular biology of thyroid cancer has
advanced significantly. These new insights have in turn unleashed a vast potential for …

Next year will mark the 20-year anniversary of the discovery that activating mutations in the
RET gene cause multiple endocrine neoplasia, type 2 (MEN2)(1, 2). It was one of those …

Carcinomas of the thyroid comprise a heterogeneous group of neoplasms with distinctive
clinical and pathological characteristics. Over the past 15 years, the application of molecular …

Medullary thyroid carcinoma is the most common cause of death among patients with
multiple endocrine neoplasia (MEN) 2. Dominant-activating mutations in the RET proto …

Medullary thyroid cancer is a rare type of neuroendocrine tumour that arises from the
parafollicular cells (C cells) of the thyroid gland. It accounts for 3%–5% of thyroid cancer …

Simple Summary Medullary thyroid carcinoma (MTC) is a rare neoplasm supported by a
strong genetic determinism. This review summarizes the genetic landscape of MTC at both …

Medullary thyroid carcinoma (MTC) is a prototype disease in the rapidly emerging field of
molecular endocrine oncology. Since its recognition in 1959, MTC has distinguished itself …

Distinct types of thyroid neoplasms are associated with mutations in specific genes.
Medullary thyroid carcinoma (MTC) constitutes about 5% of all thyroid, neoplasms and can …

Our understanding of the genomics and epigenomics of medullary thyroid carcinoma (MTC)
has advanced since the initial recognition of RET as a driver of MTC tumorigenesis in …

Introduction: Thyroid carcinoma including into four types papillary, follicular, medullary, and
anaplastic is the most common endocrine malignancy. Medullary thyroid carcinoma (MTC) is …