Inhibition of PMPMEase, a key enzyme in the polyisoprenylation pathway, induces cancer
cell death. In this study, purified PMPMEase was inhibited by the chemopreventive agent …

The involvement of hyperactive polyisoprenylated proteins in cancers has stimulated the
search for drugs to target and suppress their excessive activities. Polyisoprenylated …

The polyisoprenylation pathway enzymes have been the focus of numerous studies to better
understand the roles of polyisoprenylated proteins in eukaryotic cells and to identify novel …

Polyisoprenylated proteins (PPs) methylation by polyisoprenylated protein methyl
transferase (PPMTase) is counteracted by polyisoprenylated methylated protein methyl …

The polyisoprenylation pathway incorporates a reversible step that metabolizes
polyisoprenylated methylated proteins from the ester to the carboxylate form …

Polyisoprenylation is a set of secondary modifications involving proteins whose aberrant
activities are implicated in cancers and degenerative disorders. The last step of the pathway …

Pancreatic cancer is the most deadly neoplasm with a 5-year survival rate of less than 6%.
Over 90% of cases harbor K-Ras mutations, which are the most challenging to treat due to …

Prostate cancer (CaP) is the most frequently diagnosed cancer in US men, with an estimated
236,590 new cases and 29,720 deaths in 2013. There exists the need to identify biomarkers …

Isoprenylcysteine carboxylmethyltransferase (Icmt) catalyzes the last step of post-
translational protein prenylation, which is essential for the stability and proper functions of …

Inhibition of isoprenylcysteine carboxylmethyltransferase (Icmt), which catalyzes the final
step of oncoproteins' prenylation, targets growth and survival of various cancers. In this work …