The disposition characteristics of β‐lactam antibiotics in rats were investigated, and a
physiologically based pharmacokinetic model capable of predicting the tissue distribution …

Various pharmacokinetic parameters (disposition half-life, total body clearance, renal
clearance, hepatic clearance, volume of distribution, intrinsic clearance and volume of …

In the present study, the physiologically based pharmacokinetic model, which succeeded
previously in predicting the pharmacokinetics of beta-lactam antibiotics in rats [A. Tsuji, T …

Traditional pharmacokinetic data analysis yields an antibiotic concentration-versus-time
curve that is descriptive of drug behavior in plasma or serum (5, 11, 50). Early …

The transport mechanisms of beta-lactam antibiotics in the rat kidney and liver were studied
with an in vivo tissue-sampling single-injection technique using [3H] benzylpenicillin [(3H] …

The aim of this study was to develop a physiologically based pharmacokinetic (PB-PK)
model capable of describing and predicting terbinafine concentrations in plasma and tissues …

The two-compartment tissue accumulation pharmacokinetics of tobramycin and netilmicin
were compared in 11 normal volunteers by using a crossover design. After each 1.0-mg/kg …

The transport kinetics of amino-B-lactam antibiotics was studied by an in situ rat small
intestinal recirculating perfusion technique. The disappearance rates of the antibiotics from …

Absorption characteristics of carindacillin (CIPC) were investigated using Caco-2 cells, and
the results were compared with those of its parent drug, carbenicillin (CBPC). Uptake of …

The degradation rate, solubility, and dissolution rate of amino penicillins, amoxicillin,
ampicillin, epicillin, and cyclacillin, were determined quantitatively as a function of pH. In the …