The extent of cardiac remodeling determines survival after acute MI. However, the
mechanisms driving cardiac remodeling remain unknown. We examined the effect of …

Objective Autophagy is activated in ischemic heart diseases, but its dynamics and functional
roles remain unclear and controversial. In this study, we investigated the dynamics and role …

Background: Sepsis-induced cardiomyopathy (SIC) is a severe myocardial dysfunction
secondary to septicemia. It is a major concern owing to the high mortality and morbidity …

The aim of this study was to explore the effect and mechanism of action of resveratrol (RSV)
on cardiac function in diabetic cardiomyopathy (DCM). Hyperglycemia-induced apoptosis …

In this study, we established systemic in-vivo evidence from molecular to organism level to
explain how diabetes can aggravate myocardial ischemia-reperfusion (I/R) injury and …

Diabetic heart disease contributes to the high mortality in diabetics, although effective
clinical management is lacking. The protease inhibitor 5-[5-(2-nitrophenyl) furfuryliodine]-1 …

With heart failure leading the cause of death in the USA (Hunt), biomedical research is
fundamental to advance medical treatments for cardiovascular diseases. Animal models that …

Background Matrine might play a vital role in cardiovascular diseases progression and
treatment. Objectives We aimed to explore the protective effects and potential mechanism of …

Diabetic cancer patients were treated with doxorubicin (DOX), a potent chemotherapeutic
drug that induces cardiac toxicity; however, molecular mechanisms of cardiac toxicity in this …

Background The autophagy associated signalling pathways such as AMPK/mTOR
previously were suggested to play a crucial role in protecting from ischaemia–reperfusion …