Effect of Coadministration of Phenobarbital Sodium on N-Nitrosodiethylamine-Induced γ-Glytamyltransferase-Positive Foci and Hepatocellular Carcinoma in Rats

MA Pereira, SL Herren-Freund, AL Britt… - Journal of the …, 1984 - academic.oup.com
The effect of concurrent administration of phenobarbital on the hepatocarcinogenicity of N-
nitrosodiethylamine (diethylnitrosamine; DENA) in rats was investigated by determination of …

Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver

MA Pereira, SL Herren-Freund, RE Long - Cancer letters, 1986 - Elsevier
The dose-response relationship was determined in rats for the enhancement by
phenobarbital of diethylnitrosamine (DENA)-initiated neoplastic nodules and hepatocellular …

The effect of pre-and post-treatment with phenobarbital on the extent of γ-glutamyl transpeptidase positive foci induced in rat liver by N-nitrosomorpholine

M Schwarz, P Bannasch, W Kunz - Cancer letters, 1983 - Elsevier
Abstract Male Sprague-Dawley rats were treated with a combination of N-nitrosomorpholine
(NNM) and phenobarbital and the extent of foci positive for γ-glutamyl transpeptidase (γ-GT) …

Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver

MA Pereira, SL Herren, AL Britt, MM Khoury - Cancer Letters, 1982 - Elsevier
The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats
to enhance the incidence of gamma-glutamyltrans-peptidase (GGTase)-positive foci was …

Promoting effects of phenobarbital and 3′-methyl-4-dimethylaminoazobenzene on the appearance of γ-glutamyltranspeptidase positive foci in rat liver pretreated …

T Shirai, K Hosoda, K Hirose, M Hirose, N Ito - Cancer letters, 1985 - Elsevier
The promotion potential of phenobarbital (PB) and 3′-methyl-4-dimethylaminoazobenzene
(3′-Me-DAB) on liver carcinogenesis after initiation with various doses of …

Effects of strain, sex, route of administration and partial hepatectomy on the induction by chemical carcinogens of gamma-glutamyltranspeptidase foci in rat liver

MA Pereira, SL Herren-Freund, AL Britt, MM Khoury - Cancer letters, 1983 - Elsevier
The incidence of gamma-glutamyltranspeptidase (GGT)-positive foci induced by 0.3
mmol/kg diethylnitrosamine (DENA) followed by promotion with 500 ppm sodium …

Changes in γ-Glutamyltransferase Activity During N-2-Fluorenylacetamide-Induced Rat Hepatocarcinogenesis

ER Capouya, R Lindahl - Journal of the National Cancer …, 1983 - academic.oup.com
Abstract Changes in γ-glutamyltransferase (GGT) activity throughout the course of rat
hepatocarcinogenesis induced by brief dietary exposure to N-2-fluorenylacetamide (2-FAA) …

Pathogenesis of dimethylnitrosamine-induced hepatocellular cancer in hamster liver and lack of enhancement by phenobarbital

F Stenbäck, H Mori, K Furuya… - Journal of the National …, 1986 - academic.oup.com
The early stages of dimethylnitrosamine (CAS: 62-75-9)-induced liver cancer and the effect
of administration of phenobarbital (CAS: 50-06-6) after dimethylnitrosamine were studied in …

Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model

SL Herren-Freund, MA Pereira - Cancer letters, 1985 - Elsevier
The effect of subsequent administration of phenobarbital on the
gammaglutamyltranspeptidase (GGT) activity and on the remodeling of nodules induced by …

Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice

BA Diwan, JM Rice, JM Ward, M Ohshima, PH Lynch - Cancer letters, 1984 - Elsevier
The effects of phenobarbital (PB) and amobarbital (AB) on the rate of development of
hepatocarcinogenesis induced by N-nitrosodiethylamine (DEN) were studied in mice …