Melanin protects the skin against ultraviolet (UV) rays. It is produced in excess by UV
radiation, which causes skin disorders and pigmentation. Retinoic acid (RA) decreases the …

Skin color is primarily produced by melanin, which is a crucial pigment that protects the skin
from UV-induced damage and prevents carcinogenesis. However, accumulated melanin in …

Tyrosinase is involved in the synthesis of melanin in the skin and hair as well as
neuromelanin in the brain. This rate limiting enzyme catalyzes two critical steps (reactions) …

Of the three enzymes that regulate the biosynthesis of melanin, tyrosinase and its related
proteins TYRP-1 and TYRP-2, tyrosinase is the most important because of its ability to limit …

Novel tyrosinase inhibitors are important for pigmentation in the skin. Following extraction of
tyrosinase inhibitors from edible vegetables or fruits, we found that the Prunus persica flesh …

Abnormal accumulation of melanin pigments in the skin can be lead to hyperpigmentation
disorders and melanoma. Melanin biosynthesis is ultimately regulated by the rate-limiting …

In order to understand the effect of structure–activity relationships on melanogenesis using
B16 melanoma cells, 19 quercetin derivatives were synthesized. Among the synthesized …

Melanogenesis is a physiological process that results in the production of melanin pigment.
However, excessive accumulations of epidermal pigmentation can cause various …

Tyrosinase is a key enzyme for melanin biosynthesis, and hyperpigmentation disorders are
associated with abnormal accumulation of melanin pigments, which can be improved by …

Down‐regulation of melanin synthesis is required for recovery of pigmentary disorders and it
is known that direct inhibitors of tyrosinase, the key enzyme in melanin synthesis, such as …