Our ability to treat depression has improved with the availability of receptor-specific and
chemically diverse groups of antidepressants. Even now, most of the short-term studies …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

Although the therapeutic armamentarium available for the clinician treating major
depression has expanded substantially over the last decade, the percentage of patients with …

When an antidepressant fails to help a depressed patient, clinicians are faced with the
daunting task of choosing the next treatment. Several pharmacologic and nonpharmacologic …

Limitations by JOHN P. O'REARDON, MD; and JAY D. AMSTERDAM, MD lthough the
therapeutic armament-arium available for the clinician treating major depression has …

Treatment resistant depression (TRD) is a serious public health problem. It is estimated that
around 20-40% of patients with a major depressive episode (whether monopolar or bipolar) …

Abstract Treatment-resistant depression, or difficult-to-treat depression is emerging as a
focus of scientific endeavor. Serotonin reuptake inhibitors and serotonin norepinephrine …

Major depressive disorder is a frequent, serious disorder that usually responds partially to
treatment and leaves many patients with treatment resistance. This article reviews and …

The management of patients with depression who have failed to respond to antidepressant
medication is a common problem in general and old age psychiatry. It has been estimated …

The phenomenon of treatment-resistant depression (TRD), described as the occurrence of
an inadequate response after an adequate treatment with antidepressant agents (in terms of …