Emerging evidence points to the involvement of specialized cells of the immune system as
key drivers in the pathophysiology of cardiovascular diseases. Monocytes are an essential …

Cardiovascular diseases are the leading cause of mortality worldwide. It is widely known
that non-resolving inflammation results in atherosclerotic conditions, which are responsible …

Ischemic heart disease is a common condition and a leading cause of mortality and
morbidity. Macrophages, besides their role in host defense and tissue homeostasis, are …

Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death
worldwide. Acute MI (AMI) inflicts massive injury to the coronary microcirculation, causing …

The important contribution of monocytes and macrophages to cardiovascular disease and
heart failure pathophysiology has attracted significant attention in the past several years …

Macrophages are the primary immune cells that reside within the myocardium, suggesting
that these mononuclear phagocytes are essential in the orchestration of cardiac immunity …

In response to pathophysiological stress, the cardiac tissue undergoes profound remodeling
process that incorporates the elimination of dying resident cells, compensatory hypertrophy …

Atherosclerosis is one of the leading causes of death and disability worldwide. It is a
complex disease characterized by lipid accumulation within the arterial wall, inflammation …

The mammalian heart contains a population of resident macrophages that expands in
response to myocardial infarction and hemodynamic stress. This expansion occurs likely …

Cardiac macrophages are abundant in the healthy heart and after myocardial infarction (MI).
Different macrophage phenotypes likely promote myocardial health vs. disease. Infarct …