BACKGROUND: During the 1990s, the United States switched from combined diphtheria,
tetanus toxoids, whole-cell pertussis (DTwP) vaccines to combined acellular pertussis …

A tricomponent acellular pertussis vaccine containing pertussis toxoid, filamentous
hemagglutinin, and pertactin combined with diphtheria and tetanus toxoids (DTPa) was …

BACKGROUND. The incidence of pertussis is increasing, especially in adolescents,
attributed in part to waning of immunity after childhood immunization. Recently licensed in …

Methods. Healthy toddlers ages 12 to< 19 months were enrolled from their primary health
care settings in Maryland, North Carolina and Pennsylvania. Children were eligible if they …

The results of the following studies are reported: a longitudinal double blind trial comparing
Lederle-Takeda APDT vaccine with Lederle DTP vaccine in two, four and six month old …

The common adverse reactions associated with diphtheria, tetanus and pertussis (DTP)
vaccination are less frequent and less severe with acellular DTP (DTaP) vaccines than with …

Objective. This case-control study investigated the protective efficacy against pertussis of
three doses of a two-component acellular pertussis vaccine (manufactured by Biken in …

The last 25 years have been tumultuous in re-gard to immunization for the prevention of
pertussis. 1 Although effective vaccines became available 50 years ago, exaggerated fears …

Objective. To facilitate future vaccine reaction data collection and analysis, we sought to
determine the minimum data set required to describe accurately and to compare common …

Background. Pertussis is increasingly recognized as an important cause of cough illness in
adolescents and adults. Purpose. To evaluate the safety and antibody response to a single …