Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia

DA Gutierrez, MJ Puglisi, AH Hasty - Current diabetes reports, 2009 - Springer
Obesity is associated with increased prevalence of metabolic disorders, such as
inflammation, insulin resistance, and dyslipidemia, which can predispose an individual to …

Epigenetic regulation of adipogenesis in development of metabolic syndrome

R Pant, P Firmal, VK Shah, A Alam… - Frontiers in Cell and …, 2021 - frontiersin.org
Obesity is one of the biggest public health concerns identified by an increase in adipose
tissue mass as a result of adipocyte hypertrophy and hyperplasia. Pertaining to the …

Minireview: the adipocyte—at the crossroads of energy homeostasis, inflammation, and atherosclerosis

MW Rajala, PE Scherer - Endocrinology, 2003 - academic.oup.com
Adipose tissue evolved to efficiently store energy for times of caloric restriction. The large
caloric excess common in many Western diets has negated the need for this thrifty function …

Adipose tissue and its role in organ crosstalk

T Romacho, M Elsen, D Röhrborn, J Eckel - Acta physiologica, 2014 - Wiley Online Library
The discovery of adipokines has revealed adipose tissue as a central node in the interorgan
crosstalk network, which mediates the regulation of multiple organs and tissues. Adipose …

Adipokines: therapeutic targets for metabolic syndrome

K Kobayashi, T Inoguchi - Current drug targets, 2005 - ingentaconnect.com
For a long time it has been known that obesity (adiposity) is linked to insulin resistance.
Recently, many investigators have reported that adipocytes secrete a variety of bioactive …

Adipokines influence the inflammatory balance in autoimmunity

J Hutcheson - Cytokine, 2015 - Elsevier
Over the past few decades, our understanding of the role of adipose tissue has changed
dramatically. Far from simply being a site of energy storage or a modulator of the endocrine …

[HTML][HTML] Emerging role of adipokines as mediators in atherosclerosis

H Zhang, J Cui, C Zhang - World journal of cardiology, 2010 - ncbi.nlm.nih.gov
Atherosclerotic cardiovascular disease is a major health problem around the world. Obesity
is a primary risk factor for atherosclerosis and is associated with increased morbidity and …

Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

The role of inflamed adipose tissue in the insulin resistance

FL Torres‐Leal, MH Fonseca‐Alaniz… - Cell biochemistry …, 2010 - Wiley Online Library
In this article, we discuss inflammation associated with adipose tissue dysfunction as a
potential link with obesity‐related insulin resistance, and how obesity‐related inflammatory …

Adipokines, adiposity, and atherosclerosis

L Liu, Z Shi, X Ji, W Zhang, J Luan, T Zahr… - Cellular and Molecular …, 2022 - Springer
Characterized by a surplus of whole-body adiposity, obesity is strongly associated with the
prognosis of atherosclerosis, a hallmark of coronary artery disease (CAD) and the major …