A small number of cells in the adult pancreas are endocrine cells. They are arranged in
clusters called islets of Langerhans. The islets make insulin, glucagon, and other endocrine …

This short review presents the recent breakthroughts in our understanding of the important
steps controlling pancreas morphogenesis and differentiation, and on the transcription …

The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and
decreased β-cell numbers, raising hope for cell replacement therapy. Although human islet …

All pancreatic cell populations arise from the standard gut endoderm layer in developing
embryos, requiring a regulatory gene network to originate and maintain endocrine lineages …

▪ Abstract Type I diabetes results from the autoimmune-mediated destruction of pancreatic
beta (β) cells, which regulate blood sugar levels by secretion of insulin. Recent clinical data …

Understanding how pancreatic β cells achieve and maintain functional identity as insulin-
secreting cells is a major roadblock in our understanding of the aetiology of diabetes …

Diabetes is characterized by decreased function of insulin‐producing β cells and insufficient
insulin output resulting from an absolute (Type 1) or relative (Type 2) inadequate functional …

Diabetes mellitus represents a major healthcare burden and, due to the increasing
prevalence of type I diabetes and the complications arising from current treatments, other …

Background: Islet cell implantation and pancreas transplantation have been used as
treatments for diabetes but are limited by the shortage of donors and the requirement for …

Through the analysis of genetically modified mice a hierarchy of transcription factors
regulating pancreas specification, endocrine destiny as well as endocrine subtype …