Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …

The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …

Regulatory T (Treg) cells play a crucial role in maintaining self‐tolerance and resolution of
immune responses by employing multifaceted immunoregulatory mechanisms. However …

Regulatory T cells (Tregs) are among the most abundant suppressive cells, which infiltrate
and accumulate in the tumor microenvironment, leading to tumor escape by inducing anergy …

Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self‐and
nonself‐antigens to maintain immune homeostasis. In tumor immunity, Treg cells are …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

Regulatory T cells (Tregs) play essential roles in immune homeostasis; however, their role in
tumor microenvironment (TME) is not completely evident. Several studies reported that …

Cancer immunotherapy involving blockade of immune checkpoint molecules, such as CTLA‐
4 and PD‐1, has shown remarkable clinical success across several types of malignancies …

With the broad application of cancer immunotherapies such as immune checkpoint inhibitors
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …

Highlights•The vital role of FOXP3+ CD25+ CD4+ regulatory T (Treg) cells in tumor immunity
is described.•FOXP3+ CD25+ CD4+ Treg cells are abundantly present in tumor tissues and …