Background Genetic faults in several components of the nuclear factor-κB pathway cause
immunodeficiency. Most defects lead to combined immunodeficiency with a range of …

The noncanonical NF-κB pathway is implicated in diverse biological and immunological
processes. Monoallelic C-terminus loss-of-function and gain-of-function mutations of NFKB2 …

NF-κB signaling, acting through NFKB1 dependent canonical and NFKB2 dependent non-
canonical pathways plays a critical role in inflammatory and immune responses. Recent …

NF-κB signaling through its NFKB1-dependent canonical and NFKB2-dependent
noncanonical pathways plays distinctive roles in a diverse range of immune processes …

Background The nuclear factor κ light-chain enhancer of activated B cells (NF-κB) signaling
pathway is a key regulator of immune responses. Accordingly, mutations in several NF-κB …

Background An increasing number of NFKB1 variants are being identified in patients with
heterogeneous immunologic phenotypes. Objective To characterize the clinical and cellular …

Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous
mutations in NFKB2 have recently been established as a molecular cause of common …

To the Editor, In the last 10 years, the explosion of novel genetic etiologies of primary
immunodeficiencies (PIDs) has begun an evolution from a traditional broad descriptive …

Mutations in NFkB pathway genes can cause inborn errors of immunity (IEI), with NFKB1
haploinsufficiency being a significant etiology for common variable immunodeficiency …

In common variable immunodeficiency (CVID), heterozygous damaging NFKB1 variants
represent the most frequent monogenic cause. NFKB1 encodes the precursor p105, which …