Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

Rho GTPases play central roles in numerous cellular processes, including cell motility, cell
polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

Rho GTPases are small proteins that act as binary molecular switches in a wide range of
signalling pathways upon stimulation of cell surface receptors. Three different classes of …

Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular
processes, including cell migration, adhesion, and proliferation, by regulating the functions …

Background Relatively few genes have been shown to directly affect the metastatic
phenotype of breast cancer epithelial cells in vivo. The Rho family of proteins, including the …

The acquisition of a motile and invasive phenotype is an important step in the development
of tumors and ultimately metastasis. This step requires the abrogation of cell–cell contacts …

Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6
biological capabilities acquired during the development of human tumors. The hallmarks …