Viral pathogen detection by metagenomics and pan-viral group polymerase chain reaction in children with pneumonia lacking identifiable etiology

R Schlaberg, K Queen, K Simmon… - The Journal of …, 2017 - academic.oup.com
Background. Community-acquired pneumonia (CAP) is a leading cause of pediatric
hospitalization. Pathogen identification fails in approximately 20% of children but is critical …

Concordance in pathogen identification at the upper and lower respiratory tract of children with severe pneumonia

H Wang, X Li, Y Zheng, LM Verhagen, J Gu, L Li… - BMC infectious …, 2023 - Springer
Background Nasopharyngeal swabs are taken to determine the causative agent of
community acquired pneumonia (CAP), while the reliability of upper respiratory tract …

Community-acquired pneumonia in children: the challenges of microbiological diagnosis

CMC Rodrigues, H Groves - Journal of clinical microbiology, 2018 - Am Soc Microbiol
Community-acquired pneumonia (CAP) is the leading cause of mortality in children under 5
years of age globally. To improve the management of CAP, we must distinguish CAP from …

Addressing the analytic challenges of cross-sectional pediatric pneumonia etiology data

LL Hammitt, DR Feikin, JAG Scott… - Clinical infectious …, 2017 - academic.oup.com
Despite tremendous advances in diagnostic laboratory technology, identifying the pathogen
(s) causing pneumonia remains challenging because the infected lung tissue cannot usually …

Community-acquired pneumonia in children: myths and facts

KW Yun, R Wallihan, A Juergensen… - American journal of …, 2019 - thieme-connect.com
Community-acquired pneumonia (CAP) is the leading cause of death in children< 5 years of
age worldwide. It is also one of the most frequent infectious diseases in children, leading to …

Incidence of viral infection detected by PCR and real‐time PCR in childhood community‐acquired pneumonia: a meta‐analysis

M Wang, F Cai, X Wu, T Wu, X Su, Y Shi - Respirology, 2015 - Wiley Online Library
Several studies examining the incidence of viral infection in childhood community‐acquired
pneumonia (CAP) utilizing polymerase chain reaction (PCR) or real‐time PCR methods …

Epidemiology and microbiological investigations of community-acquired pneumonia in children admitted at the emergency department of a university hospital

A Cantais, O Mory, S Pillet, PO Verhoeven… - Journal of clinical …, 2014 - Elsevier
Background The management of children with community-acquired pneumonia (CAP) is
largely influenced by the development of new molecular diagnostic tests that allow the …

Serology enhances molecular diagnosis of respiratory virus infections other than influenza in children and adults hospitalized with community-acquired pneumonia

Y Zhang, SK Sakthivel, A Bramley, S Jain… - Journal of clinical …, 2017 - Am Soc Microbiol
Both molecular and serological assays have been used previously to determine the etiology
of community-acquired pneumonia (CAP). However, the extent to which these methods are …

Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumonia

K Hamano-Hasegawa, M Morozumi… - Journal of Infection and …, 2008 - Elsevier
We have developed a real-time reverse transcription-PCR (RT-PCR) method to detect 13
respiratory viruses: influenza virus A and B; respiratory syncytial virus (RSV) subgroup A and …

Etiology and the challenge of diagnostic testing of community-acquired pneumonia in children and adolescents

ZV Rueda, Y Aguilar, MA Maya, L López, A Restrepo… - BMC pediatrics, 2022 - Springer
Background Pneumonia is the leading cause of mortality in pediatric population. The
etiology of pneumonia in this population is variable and changes according to age and …