Understanding and targeting centrally mediated visceral pain in inflammatory bowel disease

KE Farrell, RJ Callister, S Keely - Frontiers in pharmacology, 2014 - frontiersin.org
Chronic abdominal pain is a debilitating symptom of inflammatory bowel disease (IBD): a
chronic inflammatory condition of the gastrointestinal tract, which includes Crohn's disease …

Pain and inflammatory bowel disease

K Bielefeldt, B Davis, DG Binion - Inflammatory bowel diseases, 2009 - academic.oup.com
Abdominal pain is a common symptom of inflammatory bowel disease (IBD: Crohn's
disease, ulcerative colitis). Pain may arise from different mechanisms, which can include …

Contribution of membrane receptor signalling to chronic visceral pain

M Sadeghi, A Erickson, J Castro, A Deiteren… - The international journal …, 2018 - Elsevier
Irritable bowel syndrome and inflammatory bowel disease are major forms of chronic
visceral pain, which affect over 15% of the global population. In order to identify new …

Visceral pain

DC Bulmer, C Roza - The Oxford handbook of the neurobiology …, 2018 - books.google.com
Visceral pain arising from the internal organs of the body is one of the most common types of
pain (Gebhart & Bielefeldt, 2016). The presence of visceral pain can be an indication of …

Chronic abdominal pain in IBD research initiative: unraveling biological mechanisms and patient heterogeneity to personalize treatment and improve clinical …

A Hurtado-Lorenzo, G Honig, SA Weaver… - Crohn's & Colitis …, 2021 - academic.oup.com
Abdominal pain in patients with inflammatory bowel diseases (IBDs) is very common and up
to 80% of patients experience some type of acute pain as a result of inflammation and/or …

Human visceral nociception: findings from translational studies in human tissue

JRF Hockley, ESJ Smith… - American Journal of …, 2018 - journals.physiology.org
Peripheral sensitization of nociceptors during disease has long been recognized as a
leading cause of inflammatory pain. However, a growing body of data generated over the …

Putative therapeutic targets in the treatment of visceral hyperalgesia

S Collins - Gut, 2004 - gut.bmj.com
The management of abdominal pain remains a major challenge for clinicians despite an
explosion of knowledge regarding the physiology and pathophysiology of sensory neural …

Pain management in IBD

M Grover, DA Drossman - Inflammatory Bowel Disease …, 2009 - mayoclinic.elsevierpure.com
Patients with IBD commonly suffer from abdominal pain. While the pain may originate from
worsening inflammation and/or its complications, chronic pain in IBD can have multiple …

Novel nervous system mechanisms in visceral pain

BY De Winter, A Deiteren… - Neurogastroenterology & …, 2016 - Wiley Online Library
Visceral hypersensitivity is an important factor underlying abdominal pain in functional
gastrointestinal disorders such as irritable bowel syndrome (IBS) and can result from …

Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities

RD Moloney, SM O'Mahony, TG Dinan… - Frontiers in …, 2015 - frontiersin.org
Visceral pain is a global term used to describe pain originating from the internal organs,
which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders …