VEGF gradients, receptor activation, and sprout guidance in resting and exercising skeletal muscle
F Mac Gabhann, JW Ji… - Journal of applied …, 2007 - journals.physiology.org
Extensive experimental studies have identified vascular endothelial growth factor (VEGF)
concentrations and concentration gradients as major factors in angiogenesis; however …
concentrations and concentration gradients as major factors in angiogenesis; however …
Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise
JW Ji, F Mac Gabhann… - American Journal of …, 2007 - journals.physiology.org
VEGF is a key promoter of angiogenesis and a major target of proangiogenic therapy for
peripheral arterial disease (PAD). Greater understanding of VEGF angiogenic signaling and …
peripheral arterial disease (PAD). Greater understanding of VEGF angiogenic signaling and …
The critical role of VEGF in skeletal muscle angiogenesis and blood flow
PD Wagner - Biochemical Society Transactions, 2011 - portlandpress.com
VEGF (vascular endothelial growth factor) is well known as an important molecule in
angiogenesis. Its inhibition is pursued as an anticancer therapy; its enhancement as therapy …
angiogenesis. Its inhibition is pursued as an anticancer therapy; its enhancement as therapy …
Exercise‐induced capillary growth in human skeletal muscle and the dynamics of VEGF
B Hoier, Y Hellsten - Microcirculation, 2014 - Wiley Online Library
In skeletal muscle, growth of capillaries is an important adaptation to exercise training that
secures adequate diffusion capacity for oxygen and nutrients even at high‐intensity exercise …
secures adequate diffusion capacity for oxygen and nutrients even at high‐intensity exercise …
What makes vessels grow with exercise training?
BM Prior, HT Yang, RL Terjung - Journal of applied …, 2004 - journals.physiology.org
Exercise and muscle contractions create a powerful stimulus for structural remodeling of the
vasculature. An increase in flow velocity through a vessel increases shear stress, a major …
vasculature. An increase in flow velocity through a vessel increases shear stress, a major …
Expression of VEGF receptors on endothelial cells in mouse skeletal muscle
PI Imoukhuede, AS Popel - 2012 - journals.plos.org
VEGFR surface localization plays a critical role in converting extracellular VEGF signaling
towards angiogenic outcomes, and the quantitative characterization of these parameters is …
towards angiogenic outcomes, and the quantitative characterization of these parameters is …
Exercise adaptation attenuates VEGF gene expression in human skeletal muscle
RS Richardson, H Wagner… - American Journal …, 2000 - journals.physiology.org
Angiogenesis is a component of the multifactoral adaptation to exercise training, and
vascular endothelial growth factor (VEGF) is involved in extracellular matrix changes and …
vascular endothelial growth factor (VEGF) is involved in extracellular matrix changes and …
Regional differences in expression of VEGF mRNA in rat gastrocnemius following 1 hr exercise or electrical stimulation
Background Vascular endothelial growth factor (VEGF) mRNA levels increase in rat skeletal
muscle after a single bout of acute exercise. We assessed regional differences in VEGF 165 …
muscle after a single bout of acute exercise. We assessed regional differences in VEGF 165 …
VEGF trap abolishes shear stress-and overload-dependent angiogenesis in skeletal muscle
JL Williams, D Cartland, JS Rudge, S Egginton - Microcirculation, 2006 - Taylor & Francis
Objective: To determine which elements of the angiogenic process are controlled by VEGF
under physiological conditions. Methods: VEGF Trap was administered at 10 mg· kg− 1 by …
under physiological conditions. Methods: VEGF Trap was administered at 10 mg· kg− 1 by …
Skeletal myofiber VEGF regulates contraction-induced perfusion and exercise capacity but not muscle capillarity in adult mice
AE Knapp, D Goldberg, H Delavar… - American Journal …, 2016 - journals.physiology.org
A single bout of exhaustive exercise signals expression of vascular endothelial growth factor
(VEGF) in the exercising muscle. Previous studies have reported that mice with life-long …
(VEGF) in the exercising muscle. Previous studies have reported that mice with life-long …