Background. Retrospective evidence suggests that lactate dehydrogenase, aspartate
aminotransferase, total glutathione-S-transferase (GST), alanine-aminopeptidase, N-acetyl …

There is good evidence to support the use of hypothermic machine perfusion (HMP) over
static cold storage as the favoured preservation method for deceased donor kidneys …

Hypothermic machine perfusion (HMP) is increasingly used in deceased donor kidney
transplantation, but controversy exists regarding the value of perfusion biomarkers and …

Background Donation after cardiac death (DCD) increases the number of donor kidneys but
is associated with more primary nonfunction (PNF) and delayed graft function (DGF). It has …

Background: Renal transplantation in many units is limited by the availability of donor
organs. Kidneys obtained from non-heart-beating donors (NHBD) represent an important …

Background Accurate and reliable assessment of kidney quality before transplantation is
needed to predict recipient outcomes and to optimize management and allocation of the …

Background The use of machine perfusion (MP) in kidney transplantation lowers delayed
graft function (DGF) and improves 1-year graft survival in some, but not all, grafts. These …

Although hypothermic machine perfusion (HMP) is associated with improved kidney graft
viability and function, the underlying biological mechanisms are unknown. Untargeted …

Background The metabolic processes occurring within the preserved kidney during
hypothermic machine perfusion (HMP) are not well characterized. The aim of this study was …

The lack of suitable kidney donor organs has led to rising numbers of patients with end
stage renal disease waiting for kidney transplantation. Despite decades of clinical …