The interaction between digoxin and verapamil was studied in six patients (mean age±SD,
61±5 years) with chronic atrial fibrillation. The effects of adding verapamil (240 mg/day) on …

To explore a possible interaction between digoxin and verapamil, a single‐dose kinetic
study of digoxin was performed and then repeated after 10 days of verapamil treatment in …

Single-dose investigations in healthy subjects have demonstrated substantial impairment of
renal and extrarenal clearance of digoxin during coadministration of verapamil. A …

The effects on the steady‐state digoxin pharmacokinetics of verapamil (240 mg/day) and a
new dihydropyridine calcium channel blocker, isradipine (15 mg/day), were compared …

The influence of several calcium antagonists and antiarrhythmic drugs on digoxin kinetics
and actions were investigated in 36 healthy men during digoxin steady state (0.375 mg/day) …

Conflicting conclusions have been reported about interaction of calcium channel blockers
with digoxin. The effects of verapamil (240 mg/day) and a new dihydropyridine calcium …

Quinidine is known to reduce the renal clearance of digoxin, but this effect does not
completely explain the influence of quinidine on the total clearance of digoxin. We therefore …

Verapamil has been shown to reduce total‐body digoxin clearance by 35% due to
impairments of both renal and extrarenal clearances. Our study was undertaken to evaluate …

To study the interaction between the calcium antagonist diltiazem and digoxin, a
randomized crossover trial under steady‐state conditions was carried out in 24 healthy male …

The effect of verapamil on the pharmacokinetics of digoxin was studied in 49 patients with
chronic atrial fibrillation. A dose of 240 mg/day of verapamil was given to the patients who …