ABSTRACT A universal response to changes in cellular oxygen tension is governed by a
family of heterodimeric transcription factors called hypoxia‐inducible factor (HIF). Tumor …

HIF (hypoxia-inducible factor)-3α is the third member of the HIF transcription factor family.
Whereas HIF-1α and-2α play critical roles in the cellular and systemic adaptation to hypoxia …

Cellular integrity in hypoxia is dependent on molecular adaptations dominated by the
heterodimeric transcription factor hypoxia-inducible factor (HIF). The HIF complex contains …

The hypoxia-inducible transcription factors (HIFs) play a central role in the response of cells
to hypoxia. HIFs are αβ dimers, the human α subunit having three isoforms. HIF-3α is unique …

Poorly oxygenated (hypoxic) tumors are frequently more aggressive compared to
corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily …

Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …

Hypoxia‐inducible factor 1 (HIF‐1) activates the transcription of genes involved in diverse
aspects of cellular and integrative physiology, including energy metabolism, cell growth …

Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …

Abstract Hypoxia-inducible factor 1 (HIF-1) mediates transcriptional responses to hypoxia.
HIF-1 is composed of an O2-and growth factor-regulated HIF-loc subunit and a constitutively …

Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in
mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygen …