[HTML][HTML] The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

[HTML][HTML] Aortic aneurysms: current pathogenesis and therapeutic targets

MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …

Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …

Cellular signaling in abdominal aortic aneurysm

Z Li, W Kong - Cellular signalling, 2020 - Elsevier
Abdominal aortic aneurysms (AAAs) are highly lethal cardiovascular diseases without
effective medications. However, the molecular and signaling mechanisms remain unclear. A …

Pathogenesis of abdominal aortic aneurysm: an update and look toward the future

JJ Grange, V Davis, BT Baxter - Cardiovascular surgery, 1997 - Elsevier
To date, aneurysm research has been primarily descriptive, reiterating the complex nature of
the disease process. Enhanced by the convergence of matrix biochemistry, cell biology and …

Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies

FM Davis, DL Rateri, A Daugherty - Heart, 2014 - heart.bmj.com
Aneurysms are common in the abdominal and thoracic regions of the aorta. While generally
asymptomatic, progression of aneurysms is associated with the devastating consequences …

Aortic wall inflammation in the pathogenesis, diagnosis and treatment of aortic aneurysms

G Skotsimara, A Antonopoulos, E Oikonomou… - Inflammation, 2022 - Springer
The role of inflammation in the development of aortic aneurysms is emerging, along with the
potential diagnostic and therapeutical potential of this correlation. Abdominal aorta …

[HTML][HTML] Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

Abdominal aortic aneurysms: an autoimmune disease?

VP Jagadesham, DJA Scott, SR Carding - Trends in molecular medicine, 2008 - cell.com
Abdominal aortic aneurysms (AAAs) are a multifactorial degenerative vascular disorder. One
of the defining features of the pathophysiology of aneurysmal disease is inflammation …

[HTML][HTML] Dysregulations of key regulators of angiogenesis and inflammation in abdominal aortic aneurysm

D Zalewski, P Chmiel, P Kołodziej, G Borowski… - International Journal of …, 2023 - mdpi.com
Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized
weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed …