Apigenin induces ROS‐dependent apoptosis and ER stress in human endometriosis cells

S Park, W Lim, FW Bazer, G Song - Journal of cellular …, 2018 - Wiley Online Library
Apigenin is a plant‐derived flavonoid having antiproliferative, anti‐inflammatory, and anti‐
angiogenic properties in chronic and metabolic diseases, and cancers. However, the …

Naringenin induces mitochondria-mediated apoptosis and endoplasmic reticulum stress by regulating MAPK and AKT signal transduction pathways in endometriosis …

S Park, W Lim, FW Bazer, G Song - MHR: Basic science of …, 2017 - academic.oup.com
STUDY QUESTION Does the flavonoid naringenin inhibit proliferation of human
endometriosis cells? SUMMARY ANSWER Naringenin suppresses proliferation and …

Oxidative stress triggered by apigenin induces apoptosis in a comprehensive panel of human cervical cancer‐derived cell lines

RP Souza, PS Bonfim-Mendonça… - Oxidative medicine …, 2017 - Wiley Online Library
Recently, the cytotoxic effects of apigenin (4′, 5, 7‐trihydroxyflavone), particularly its
marked inhibition of cancer cell viability both in vitro and in vivo, have attracted the attention …

Artemisia leaf extract induces apoptosis in human endometriotic cells through regulation of the p38 and NFκB pathways

JH Kim, SH Jung, YI Yang, JH Ahn, JG Cho… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia leaves have long been used for the
treatment of gynecological disorders, including infertility and dysmenorrhea, which can be …

Anandamide oxidative metabolism-induced endoplasmic reticulum stress and apoptosis

M Almada, BM Fonseca, C Amaral, M Diniz-da-Costa… - Apoptosis, 2017 - Springer
Abstract The Endocannabinoid System (ECS) has been recognized as a crucial player in
human reproduction. Changes in the levels of anandamide (AEA), the main …

Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells

Y Qi, Z Ding, Y Yao, F Ren, M Yin… - Experimental and …, 2020 - spandidos-publications.com
Ovarian cancer (OC) is one of the prominent causes of mortality in female patients
diagnosed with gynecologic malignancies. While it has previously been demonstrated that …

[HTML][HTML] Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum …

YC Liang, Q Zhong, RH Ma, ZJ Ni, K Thakur… - Journal of Functional …, 2022 - Elsevier
Several experimental and biological studies have emphasized the tumor suppression
efficacy and low toxicity of Apigenin (API); however, its exact underlying mechanism on …

[HTML][HTML] Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

B Wang, XH Zhao - Oncology reports, 2017 - spandidos-publications.com
Apigenin is one of the plant-originated flavones with anticancer activities. In this study,
apigenin was assessed for its in vitro effects on a human colon carcinoma line (HCT‑116 …

[HTML][HTML] Apigenin, a natural flavonoid, promotes autophagy and ferroptosis in human endometrial carcinoma Ishikawa cells in vitro and in vivo

Y Liang, Q Zhong, R Ma, Z Ni, K Thakur, J Zhang… - Food Science and …, 2023 - Elsevier
Apigenin, a natural flavonoid has been reported against a variety of cancer types. However,
it is unclear whether apigenin can promote autophagy and ferroptosis in Ishikawa cells …

[HTML][HTML] Apigenin inhibits tumor necrosis factor α–induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells

K Suou, F Taniguchi, Y Tagashira, T Kiyama… - Fertility and sterility, 2011 - Elsevier
Apigenin suppressed tumor necrosis factor α–induced cell proliferation and prostaglandin
E2 expression via the attenuation of nuclear factor κB pathway in endometriotic stromal cells …