MRI investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury: a prospective longitudinal study

P Freund, N Weiskopf, J Ashburner, K Wolf… - The Lancet …, 2013 - thelancet.com
Background In patients with chronic spinal cord injury, imaging of the spinal cord and brain
above the level of the lesion provides evidence of neural degeneration; however, the spatial …

MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers

P Freund, M Seif, N Weiskopf, K Friston… - The Lancet …, 2019 - thelancet.com
Traumatic spinal cord injury occurs when an external physical impact damages the spinal
cord and leads to permanent neurological dysfunction and disability, and it is associated …

[HTML][HTML] Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury

M Seif, A Curt, AJ Thompson, P Grabher, N Weiskopf… - NeuroImage: Clinical, 2018 - Elsevier
Objective To reveal the immediate extent of trauma-induced neurodegenerative changes
rostral to the level of lesion and determine the predictive clinical value of quantitative MRI …

Progressive neurodegeneration following spinal cord injury: implications for clinical trials

G Ziegler, P Grabher, A Thompson, D Altmann… - Neurology, 2018 - AAN Enterprises
Objective To quantify atrophy, demyelination, and iron accumulation over 2 years following
acute spinal cord injury and to identify MRI predictors of clinical outcomes and determine …

Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers

M Seif, CAM Gandini Wheeler-Kingshott… - Spinal Cord, 2019 - nature.com
Traumatic spinal cord injury (SCI) leads to immediate neuronal and axonal damage at the
focal injury site and triggers secondary pathologic series of events resulting in sensorimotor …

Tracking sensory system atrophy and outcome prediction in spinal cord injury

P Grabher, MF Callaghan, J Ashburner… - Annals of …, 2015 - Wiley Online Library
Objective In patients with subacute spinal cord injury (SCI), the motor system undergoes
progressive structural changes rostral to the lesion, which are associated with motor …

Brain changes after spinal cord injury, a quantitative meta-analysis and review

LS Dahlberg, L Becerra, D Borsook… - … & Biobehavioral Reviews, 2018 - Elsevier
Abstract Spinal Cord Injuries (SCI) lead to alterations in brain structure and brain function by
direct effects of nerve damage, by secondary mechanisms, and also by longer term injury …

Motor recovery at 6 months after admission is related to structural and functional reorganization of the spine and brain in patients with spinal cord injury

J Hou, Z Xiang, R Yan, M Zhao, Y Wu… - Human brain …, 2016 - Wiley Online Library
This study aimed to explore structural and functional reorganization of the brain in the early
stages of spinal cord injury (SCI) and identify brain areas that contribute to motor recovery …

Cerebral activation is correlated to regional atrophy of the spinal cord and functional motor disability in spinal cord injured individuals

H Lundell, MS Christensen, D Barthélemy… - Neuroimage, 2011 - Elsevier
Recovery of function following lesions in the nervous system requires adaptive changes in
surviving circuitries. Here we investigate whether changes in cerebral activation are …

Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

G David, S Mohammadi, AR Martin… - Nature Reviews …, 2019 - nature.com
Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …