Peripheral galanin receptor 2 as a target for the modulation of pain
RP Hulse, LF Donaldson… - Pain research and …, 2012 - Wiley Online Library
The neuropeptide galanin is widely expressed in the nervous system and has an important
role in nociception. It has been shown that galanin can facilitate and inhibit nociception in a …
role in nociception. It has been shown that galanin can facilitate and inhibit nociception in a …
Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia
Background: Galanin is expressed at low levels in the intact sensory neurons of the dorsal
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …
Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice
RJP Pope, FE Holmes, NC Kerr, D Wynick - Molecular Pain, 2010 - journals.sagepub.com
The neuropeptide galanin is widely expressed in both the central and peripheral nervous
systems and is involved in many diverse biological functions. There is a substantial data set …
systems and is involved in many diverse biological functions. There is a substantial data set …
A new gal in town: a systematic review of the role of galanin and its receptors in experimental pain
D Fonseca-Rodrigues, A Almeida, F Pinto-Ribeiro - Cells, 2022 - mdpi.com
Galanin is a neuropeptide expressed in a small percentage of sensory neurons of the dorsal
root ganglia and the superficial lamina of the dorsal horn of the spinal cord. In this work, we …
root ganglia and the superficial lamina of the dorsal horn of the spinal cord. In this work, we …
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
BJ Kerr, WBJ Cafferty, YIK Gupta… - European Journal of …, 2000 - Wiley Online Library
The neuropeptide galanin has been identified as a potential neurotransmitter/
neuromodulator within the central nervous system. In the present study, the role of …
neuromodulator within the central nervous system. In the present study, the role of …
The participation of galanin in pain processing at the spinal level
Abstract Galanin, a 29-amino-acid peptide expressed in dorsal root ganglia (DRG) and
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
Galanin and spinal nociceptive mechanisms: recent advances and therapeutic implications
XJ Xu, T Hökfelt, T Bartfai, Z Wiesenfeld-Hallin - Neuropeptides, 2000 - Elsevier
Galanin is a peptide consisting of 29 or 30 (in humans) amino acids that is present in
sensory and spinal dorsal horn neurons. Endogenous galanin may have an important …
sensory and spinal dorsal horn neurons. Endogenous galanin may have an important …
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors
Galanin is a 29-aa neuropeptide with a complex role in pain processing. Several galanin
receptor subtypes are present in dorsal root ganglia and spinal cord with a differential …
receptor subtypes are present in dorsal root ganglia and spinal cord with a differential …
Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor
Background: Galanin is expressed in a small percentage of intact small diameter sensory
neurons of the dorsal root ganglia and in the afferent terminals of the superficial lamina of …
neurons of the dorsal root ganglia and in the afferent terminals of the superficial lamina of …
Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse—possible implications for pain processing
P Brumovsky, K Hygge-Blakeman, MJ Villar… - Journal of Chemical …, 2006 - Elsevier
The distribution of galanin was studied in the lumbar 5 dorsal root ganglia (DRGs) and
spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing …
spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing …