Myocardial fibrosis can be defined as an abnormal increase in collagen concentration of
either ventricle. This accumulation of collagen, represented predominantly by fibrillar type I …

The major risk factor associated with the appearance of adverse cardiovascular events and
outcome attributable to cardiovascular disease is left ventricular hypertrophy (LVH). Why this …

The interstitium of the myocardium is composed of predominantly type I collagen; type III
collagen is present to a lesser extent. The fibrillar collagens serve as tethers between …

In hypertensive heart disease, reactive myocardial fibrosis represents as an excessive
accumulation of fibrillar collagen within the normal connective tissue structures of the …

ymptomatic heart failure and sudden cardiac death are worldwide health problems. In the
hopes of reducing S the morbidity and mortality associated with myocardial failure and …

In this report we review the replacement (ie, scarring) and reactive (ie, perivascular and
interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector …

Changes in the composition of cardiac tissue develop in hypertensive patients with left
ventricular hypertrophy (ie, hypertensive heart disease) and lead to structural remodeling of …

The accumulation of collagen within the myocardium is termed fibrosis. In left ventricular
pressure overload a reactive interstitial fibrosis, having distinctive biochemical and structural …

There is a complex extracellular structural matrix in the heart. This matrix appears to be
composed of a variety of fibrils and fibers extending from the cell surface to the basal lamina …

An abnormal elevation in collagen concentration or myocardial fibrosis occurs in the
hypertrophied left ventricle of the rat with renovascular hypertension (RHT). The structural …