Myocardial fibrosis resulting from arterial hypertension alters myocardial structure and
function. Myocardial fibrosis is characterized by a pathological accumulation of types I and III …

Collagen which is present in the myocardium in relatively small amounts is the most
abundant structural protein of the connective tissue network. Its structural organization …

Limiting Fibrosis after Myocardial Infarction Page 1 n engl j med 360;15 nejm.org april 9, 2009
1567 clinical implications of basic research The new england journal of medicine Limiting …

The extracellular collagen matrix of the myocardium plays an important role in maintaining
muscle fiber and cardiac alignment and ventricular shape and size. It also influences tissue …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Composed of type I and III collagens, the valve leaflets, chordae tendineae and collagen
matrix of the myocardium form a structural continuum. Synthesized by cardiac fibroblasts …

A substantial increase in fibrillar collagen has been wx observed in the cardiac ventricles of
animals 1 and wx humans 2 with arterial hypertension. Either reactive or reparative …

Eighteen different collagen types have now been identified, at least five of which are found
in the extracellular matrix of the heart. The interstitial collagens, types I and III are the most …

Objective: Myocardial fibrosis is an important determinant of pathological hypertrophy. In two
experimental models of arterial hypertension the purpose of the study was (a) to determine …

The cardiac interstitium is composed of non-myocyte cells and a structural fibrillar protein
network which plays a dominant role in governing the structure, architecture, and …