Cardiac muscle is tethered within a fibrillar collagen matrix that serves to maximize force
generation. In the human pressure-overloaded, hypertrophied left ventricle, collagen …

The normal myocardium is composed of a variety of cells: cardiac myocytes and
noncardiomyocytes, which include endothelial and vascular smooth muscle cells and …

Fibroblast fibrous tissue formation follows an inflam-matory cell response that appears at
sites of cardiomyocyte necrosis, a “dirty” form of cell death. In replacing these lost cells, such …

Left ventricular hypertrophy is a major risk factor associated with the appearance of adverse
cardiovascular events. A distortion in myocardial structure, mediated by an abnormal …

While the term “fibrosis” can be misleading in terms of the complex patterns and processes
of myocardial extracellular matrix (ECM) remodeling, fibrillar collagen accumulation is a …

Left ventricular hypertrophy (LVH) is a major risk factor associated with the emergence of
symptomatic congestive heart failure. Cardiac myocyte excitation‐contraction coupling has …

The myocardium consists of a muscle fibre array surrounded and interspersed by a network
of connective tissue, principally collagen, which maintains the functional integrity of the …

Heart failure has reached epidemic proportions among the elderly, in whom it is most often
attributable to an ischemic cardiomyopathy (ICM) with previous myocardial infarction …

Myocardial fibrosis and abnormal myocardial collagen content are common in many forms of
pathological cardiac hypertrophy, including that mediated by pressure overload. Recently, in …

Objectives: We sought to assess the distribution of collagen deposits and collagen
degradation in hypertensive patients with either systolic heart failure (SHF) or diastolic heart …