A major contribution to the mechanical strength of the heart is provided by a continuous
fibrillar collagen network embracing individual myocytes and forming an interstitial and …

See article by Bishop et al.[26](pages 57–67) in this pacing in dogs, were associated with
activation of RAAS issue. and progressive increase in preload. There, myocardial fibrosis …

A collagen network, composed largely of type I and III fibrillar collagens, is found in the
heart's interstitial space. This network has multiple functions, including the preservation of …

The inappropriate deposition of extracellular matrix within the heart (termed cardiac fibrosis)
is associated with nearly all types of heart disease, including ischemic, hypertensive …

Ischemic heart disease is a complex and diverse clinical syndrome in which an imbalance
between blood supply and demand is created by complete or partial occlusion of a major …

Cardiac fibrosis is one of the deleterious events accompanying hypertension that may be
implicated in the progression toward heart failure. To determine the mechanisms involved in …

Progressive deterioration of left ventricular (LV) function is a characteristic feature of the
heart failure (HF) state. The mechanism or mechanisms responsible for this hemodynamic …

The extracellular matrix (ECM) provides structural support and a microenvironmentfor
soluble extracellular molecules. ECM is comprised of numerous proteins which can be …

There is a complex network of collagen throughout the heart. It is composed of a hierarchy of
fibrils and fibers ranging from 10 nm to 2–3 microns in diameter. This network can be broken …

Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …