Myocardial fibrosis is the excessive deposition of extracellular matrix proteins, including
collagens, in the heart. In cardiomyopathies, the formation of interstitial fibrosis and/or …

BACKGROUND Ischemic cardiomyopathy is characterized by myocyte loss, reactive cellular
hypertrophy, and ventricular scarring. However, the relative contribution of these tissue and …

The structural nature of fibrillar collagen involved in the replacement fibrosis which
accompanies discrete areas of cell necrosis remains uncertain, as does its influence on the …

Cardiac stress can induce morphological, structural and functional changes of the heart,
referred to as cardiac remodeling. Myocardial infarction or sustained overload as a result of …

OBJECTIVE: Characterization of a distinct, and as yet unexplained phenotype of sudden
cardiac death (SCD). BACKGROUND: In a subgroup of patients with SCD, postmortem …

OBJECTIVES.: The aim of this study was to quantify total collagen and the type I/type III
collagen ratio and their localization in hearts with dilated cardiomyopathy. BACKGROUND …

Collagen is the most important component of the extracellular matrix of the myocardium; it
supports the myocytes and maintains the architecture of the heart. Collagen also participates …

Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a
result of cardiac fibroblast (CFB) activation and differentiation into myofibroblasts …

Progressive myocardial fibrosis, including the accumulation of collagen within the adventitia
of intramyocardial coronary arteries, is seen in the hypertrophied rat myocardium secondary …