Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …

Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Myeloid malignancies, including acute myeloid leukaemia (AML), arise from the expansion
of haematopoietic stem and progenitor cells that acquire somatic mutations. Bulk molecular …

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells
(HSCs), leading to clonal haematopoiesis. These lesions are precursors for blood cancers …

BACKGROUND Somatic mutations accumulate in normal tissues as a function of time. The
great majority of these mutations have no effect on fitness, so selection does not act upon …

Several genetic alterations characteristic of leukemia and lymphoma have been detected in
the blood of individuals without apparent hematological malignancies. The Cancer Genome …

Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …

The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …

Haematopoiesis, the process of mature blood and immune cell production, is functionally
organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent …

Haematopoietic stem cells drive blood production, but their population size and lifetime
dynamics have not been quantified directly in humans. Here we identified 129,582 …