INVESTIGATIONS ON the pathogenesis of cancer metastasis to bone have received
increased attention by scientists worldwide. This is good news for patients that suffer from …

This authoritative survey discusses how tumor cells cause bone metastases by producing
both local and systemic factors that disrupt the balance between bone formation and bone …

Bone metastases occur in approximately 80% of patients with advanced cancer. They are
characterized by cancer cell growth and bone destruction that cause pain, fractures, anemia …

Some of the most common human cancers, including breast cancer, prostate cancer, and
lung cancer, metastasize with avidity to bone. What is the basis for their preferential growth …

Metastasis is a final stage of tumor progression. Breast and prostate cancer cells
preferentially metastasize to bone, wherein they cause incurable osteolytic and osteoblastic …

In patients with advanced disease, several cancer types frequently metastasize to the
skeleton, where they cause bone destruction. Osteolytic metastases are incurable and …

BACKGROUND This review summarizes evidence that the formation of bone metastases is
the result of multiple synergistic cellular and molecular interactions between metastatic cells …

Bone metastases ultimately result from a complex interaction between cancer cells and
bone microenvironment. However, prior to the colonization of the bone, cancer cells must …

Bone is one of the most frequent sites of metastasis in patients with malignancies. Up to 90%
of patients with multiple myeloma, and 60% to 75% patients with prostate cancer and breast …

In human cancers, bone is a common site for metastasis. It is well known that metastasis is
the cause of morbidity and mortality in patients with cancer. Both breast and prostate …