Effects of pharmacologic treatment for neonatal abstinence syndrome on DNA methylation and neurobehavior: a prospective cohort study

M Camerota, JM Davis, LM Dansereau… - The Journal of …, 2022 - Elsevier
Objective To determine whether pharmacologic treatment for neonatal abstinence syndrome
(NAS) is associated with changes in DNA methylation (DNAm) of the mu-opioid receptor …

Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome

EM Wachman, MJ Hayes, BM Lester, N Terrin… - The Journal of …, 2014 - Elsevier
Objective Neonatal abstinence syndrome (NAS) from in utero opioid exposure is highly
variable with genetic factors appearing to play an important role. Epigenetic changes in …

Epigenetic variation in OPRM1 gene in opioid‐exposed mother‐infant dyads

EM Wachman, MJ Hayes, H Shrestha… - Genes, Brain and …, 2018 - Wiley Online Library
Neonatal abstinence syndrome (NAS) due to in‐utero opioid exposure has significant
variability of severity. Preliminary studies have suggested that epigenetic variation within the …

The genetics and epigenetics of neonatal abstinence syndrome

EM Wachman, LA Farrer - Seminars in Fetal and Neonatal Medicine, 2019 - Elsevier
Neonatal abstinence syndrome (NAS) due to in-utero opioid exposure is a growing
epidemic with significant variability in clinical presentation and severity. Currently, NAS …

Variations in opioid receptor genes in neonatal abstinence syndrome

EM Wachman, MJ Hayes, R Sherva, MS Brown… - Drug and alcohol …, 2015 - Elsevier
Background There is significant variability in the severity of neonatal abstinence syndrome
(NAS) due to in-utero opioid exposure. We wanted to determine if single nucleotide …

Increased DNA methylation of ABCB1, CYP2D6, and OPRM1 genes in newborn infants of methadone-maintained opioid-dependent mothers

P McLaughlin, H Mactier, C Gillis, T Hickish… - The Journal of …, 2017 - Elsevier
Objective To investigate whether in utero opioid exposure, which has been linked to adverse
neurodevelopmental and social outcomes, is associated with altered DNA methylation of …

Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity

EM Wachman, MJ Hayes, R Sherva… - … American journal on …, 2017 - Wiley Online Library
Background and Objectives There is significant variability in severity of neonatal abstinence
syndrome (NAS) due to in utero opioid exposure. Our previous study identified single …

[HTML][HTML] The genomics of neonatal abstinence syndrome

FS Cole, DJ Wegner, JM Davis - Frontiers in Pediatrics, 2017 - frontiersin.org
Significant variability has been observed in the development and severity of neonatal
abstinence syndrome (NAS) among neonates exposed to prenatal opioids. Since maternal …

Variations in infant CYP2B6 genotype associated with the need for pharmacological treatment for neonatal abstinence syndrome in infants of methadone-maintained …

H Mactier, P McLaughlin, C Gillis… - American journal of …, 2017 - thieme-connect.com
Background Neonatal abstinence syndrome (NAS) in infants of methadone-maintained
opioid-dependent (MMOD) mothers cannot be predicted in individual cases. We …

[HTML][HTML] A review of the genomics of neonatal abstinence syndrome

E Yen, N Gaddis, L Jantzie, JM Davis - Frontiers in Genetics, 2023 - frontiersin.org
Neonatal abstinence syndrome (NAS) is a constellation of signs of withdrawal occurring
after birth following in utero exposure to licit or illicit opioids. Despite significant research and …