Multidrug resistance pathogens causing infections and illness remain largely untreated
clinically. Efflux pumps are one of the primary processes through which bacteria develop …

Multi-drug resistance (MDR) bacteria pose a significant threat to our ability to effectively treat
infections due to the development of several antibiotic resistant mechanisms. A major …

The AdeABC efflux pump is an important mechanism causing multidrug resistance in
Acinetobacter baumannii, and its main component AdeB can recognize carbapenems …

Multidrug resistance (MDR) poses a severe threat to human health. The existence of efflux
pumps primarily contributes to resistance in Gram-negative bacterial infections. Efflux pump …

Efflux pumps have been reported as one of the significant mechanisms by which bacteria
evade the effects of multiple antibiotics. The tripartite efflux pump MexAB-OprM in …

Optimization of compound permeation into Gram-negative bacteria is one of the most
challenging tasks in the development of antibacterial agents. Two permeability barriers─ …

The structure and functioning of multidrug efflux systems provide us with a better
understanding of the transport of various antibiotics, thus giving a path for the discovery of …

Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics
rendering the treatment of infections very difficult. A main mechanism attributed to the …

Multidrug efflux is a major contributor to antibiotic resistance in Gram-negative bacterial
pathogens. Inhibition of multidrug efflux pumps is a promising approach for reviving the …

Resistance to antibiotics is a growing problem worldwide and occurs in part due to the
overexpression of efflux pumps responsible for the removal of antibiotics from bacterial cells …