Synthetic living machines: A new window on life

MR Ebrahimkhani, M Levin - Iscience, 2021 - cell.com
Increased control of biological growth and form is an essential gateway to transformative
medical advances. Repairing of birth defects, restoring lost or damaged organs, normalizing …

Synthetic morphogenesis

BP Teague, P Guye, R Weiss - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Throughout biology, function is intimately linked with form. Across scales ranging from
subcellular to multiorganismal, the identity and organization of a biological structure's …

Mechanobiological approaches to synthetic morphogenesis: learning by building

M Matejčić, X Trepat - Trends in Cell Biology, 2023 - cell.com
Tissue morphogenesis occurs in a complex physicochemical microenvironment with limited
experimental accessibility. This often prevents a clear identification of the processes that …

Programming morphogenesis through systems and synthetic biology

JJ Velazquez, E Su, P Cahan, MR Ebrahimkhani - Trends in biotechnology, 2018 - cell.com
Mammalian tissue development is an intricate, spatiotemporal process of self-organization
that emerges from gene regulatory networks of differentiating stem cells. A major goal in …

Synthetic morphology with agential materials

J Davies, M Levin - Nature Reviews Bioengineering, 2023 - nature.com
Bioengineering can address many important needs, from transformative biomedicine to
environmental remediation. In addition to practical applications, the construction of new …

Engineering tissue-scale properties with synthetic cells: Forging one from many

AJ Lin, AZ Sihorwala, B Belardi - ACS Synthetic Biology, 2023 - ACS Publications
In metazoans, living cells achieve capabilities beyond individual cell functionality by
assembling into multicellular tissue structures. These higher-order structures represent …

[图书][B] Mechanisms of morphogenesis

JA Davies - 2023 - books.google.com
Mechanisms of Morphogenesis, Third Edition offers a bottom-up discussion of mechanisms
of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes …

Synthetic developmental biology: build and control multicellular systems

MR Ebrahimkhani, M Ebisuya - Current opinion in chemical biology, 2019 - Elsevier
Highlights•Synthetic developmental biology is an emerging area of science that integrates
synthetic biology and developmental biology.•Developmental mechanisms can be …

[HTML][HTML] Synthetic developmental biology: Engineering approaches to guide multicellular organization

I Zarkesh, MK Ashtiani, Z Shiri, S Aran, T Braun… - Stem Cell Reports, 2022 - cell.com
Multicellular organisms of various complexities self-organize in nature. Organoids are in
vitro 3D structures that display important aspects of the anatomy and physiology of their in …

Building complex life through self-organization

MM Sthijns, VLS LaPointe… - … Engineering Part A, 2019 - liebertpub.com
Cells are inherently conferred with the ability to self-organize into the tissues and organs
comprising the human body. Self-organization can be recapitulated in vitro and recent …