Chemotherapeutic drugs have a common intent to activate apoptosis in tumor cells.
However, master regulators of apoptosis (eg, p53, p16/CDKN2A) are frequently genetically …

Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic
approach to treating this prevalent disease employs agents that modify cancer cell …

Carcinogenesis is a mechanistically complex and variable process with a plethora of
underlying genetic causes. Cancer development comprises a multitude of steps that occur …

In developing new and more successful therapies for preventing and treating cancer, it is
critical to understand what normally regulates cell proliferation and cell death and what are …

Cell division and cell death are fundamental processes governing growth and development
across the tree of life. This relationship represents an evolutionary link between cell cycle …

Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

Tumour cells undergo uncontrolled proliferation, yet tumours most often originate from adult
tissues, in which most cells are quiescent. So, the proliferative advantage of tumour cells …

Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

Treatment-persistent residual tumors impede curative cancer therapy. To understand this
cancer cell state we generated models of treatment persistence that simulate the residual …

The cancer stem cell hypothesis is an evolving concept of oncogenesis that has recently
gained wide acceptance. In its simplest form this hypothesis suggests that many if not all …