Chronic obstructive pulmonary disease presents with heterogenous inflammation and
altered lung structure. The contribution of airway and parenchymal structural change to …

Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

Asthma is a heterogeneous, chronic airway disease resulting from inflammation, airway
hyperresponsiveness and remodeling as well as abnormal mucus secretions that obstruct …

Pulmonary fibrosis, characterized by excessive collagen deposition in the lungs, comprises
a key and debilitating component of chronic lung diseases. Methods are lacking for the …

The mouse is now the primary animal used to model a variety of lung diseases. To study the
mechanisms that underlie such pathologies, phenotypic methods are needed that can …

Traditionally a discipline based on physiology for the functional assessment of patients with
lung disease, pulmonary medicine has been moving over the past decade into the realm of …

Development of new therapeutics for lung diseases requires good modeling systems in
which to test hypotheses. Often, how lung diseases are modeled in vivo, are not at all …

The lung is a complex organ whose primary function is to supply the body with sufficient
oxygen to meet its metabolic needs and to remove the carbon dioxide formed as a byproduct …

In vivo imaging is an important tool for preclinical studies of lung function and disease. The
widespread availability of multimodal animal imaging systems and the rapid rate of …

Breathing involves fluid-solid interactions in the lung; however, the lack of experimental data
inhibits combining the mechanics of air flow to airway deformation, challenging the …