The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes

R Niranjan - Molecular neurobiology, 2014 - Springer
Neuroinflammation plays a key role in the pathogenesis of Parkinson's disease (PD).
Epidemiologic, animal, human, and therapeutic studies support the role of oxidative stress …

[PDF][PDF] Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy

MG Tansey, TC Frank-Cannon, MK McCoy, JK Lee… - Front Biosci, 2008 - researchgate.net
Overview 3. Clinical and epidemiological evidence for inflammation in Parkinson's Disease
3.1. Cell types involved in neuroinflammation 3.2. Inflammatory mediators in …

Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease

P Troncoso-Escudero, A Parra, M Nassif… - Frontiers in …, 2018 - frontiersin.org
Neuroinflammation is one of the most important processes involved in the pathogenesis of
Parkinson's disease (PD). The current concept of neuroinflammation comprises an …

Inflammatory response in Parkinson's disease

J Yan, Q Fu, L Cheng, M Zhai… - Molecular …, 2014 - spandidos-publications.com
Parkinson's disease (PD) is one of the most common age‑related neurodegenerative
diseases, which results from a number of environmental and inherited factors. PD is …

Evidence of inflammatory system involvement in Parkinson's disease

Y Chao, SC Wong, EK Tan - BioMed research international, 2014 - Wiley Online Library
Parkinson's disease (PD) is a chronic neurodegenerative disease underpinned by both
genetic and environmental etiologic factors. Recent findings suggest that inflammation may …

The involvement of neuroinflammation in the onset and progression of Parkinson's disease

A Jurcau, FL Andronie-Cioara… - International Journal of …, 2023 - mdpi.com
Parkinson's disease is a neurodegenerative disease exhibiting the fastest growth in
incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is …

Significant roles of neuroinflammation in Parkinson's disease: therapeutic targets for PD prevention

Y Lee, S Lee, SC Chang, J Lee - Archives of pharmacal research, 2019 - Springer
Glial cells outnumber neurons in the brain and play important roles in the neuroinflammation
that accompanies brain damage in neurodegenerative diseases. In Parkinson's disease …

The association of Parkinson's disease pathogenesis with inflammation

S Saiki - Rinsho Shinkeigaku= Clinical Neurology, 2014 - europepmc.org
Recent research on pathogenesis of neurodegenerative diseases has revealed that
neuroinflammation derived from glial activation enhances the progression of devastating …

Neuroinflammation in Parkinson's disease–putative pathomechanisms and targets for disease-modification

A Grotemeyer, RL McFleder, J Wu… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is a progressive and debilitating chronic disease that affects more
than six million people worldwide, with rising prevalence. The hallmarks of PD are motor …

Neuroinflammatory responses and Parkinson'disease: pathogenic mechanisms and therapeutic targets

L Yang, K Mao, H Yu, J Chen - Journal of Neuroimmune Pharmacology, 2020 - Springer
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorders of the central nervous system, which mainly impairs the motor system. However …