Immune responses in Parkinson's disease: interplay between central and peripheral immune systems

X Su, HJ Federoff - BioMed research international, 2014 - Wiley Online Library
The etiology of Parkinson's disease (PD) is complex and most likely involves numerous
environmental and heritable risk factors. Recent studies establish that central and peripheral …

[HTML][HTML] Increased levels of pro-inflammatory and anti-inflammatory cellular responses in Parkinson's disease patients: search for a disease indicator

L Yang, C Guo, J Zhu, Y Feng, W Chen… - … Medical Journal of …, 2017 - ncbi.nlm.nih.gov
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder and it arises when most of the dopaminergic neurons of substantia nigra region die …

Linking neuroinflammation and neurodegeneration in Parkinson's disease

G Gelders, V Baekelandt… - Journal of immunology …, 2018 - Wiley Online Library
Neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease
(AD) impose a pressing burden on our developed and consequently aging society …

Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention

MG Tansey, MK McCoy, TC Frank-Cannon - Experimental neurology, 2007 - Elsevier
Most acute and chronic neurodegenerative conditions are accompanied by
neuroinflammation; yet the exact nature of the inflammatory processes and whether they …

[HTML][HTML] iPSC-derived microglia as a model to study inflammation in idiopathic Parkinson's disease

K Badanjak, P Mulica, S Smajic… - Frontiers in Cell and …, 2021 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disease with unknown cause in the
majority of patients, who are therefore considered “idiopathic”(IPD). PD predominantly …

[HTML][HTML] The biomarkers of immune dysregulation and inflammation response in Parkinson disease

L Chen, M Mo, G Li, L Cen, L Wei, Y Xiao… - Translational …, 2016 - Springer
Parkinson's disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy
bodies deposited in midbrain. In ageing, the environmental and genetic factors work …

Neuroinflammation in Parkinson's disease: triggers, mechanisms, and immunotherapies

T Wang, C Shi, H Luo, H Zheng, L Fan… - The …, 2022 - journals.sagepub.com
Parkinson's disease (PD) is a heterogeneous neurodegenerative disease involving multiple
etiologies and pathogenesis, in which neuroinflammation is a common factor. Both …

Role of neuroinflammation and latent transcription factors in pathogenesis of Parkinson's disease

R Pal, PC Tiwari, R Nath, KK Pant - Neurological research, 2016 - Taylor & Francis
Parkinson's disease (PD) the second most common age-associated progressive
neurodegenerative disorder is characterized by loss of dopaminergic neurons, cytoplasmic …

[HTML][HTML] Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease …

DG Walker, LF Lue, G Serrano, CH Adler… - Frontiers in …, 2016 - frontiersin.org
Evidence of inflammation has been consistently associated with pathology in Parkinson's
disease (PD)-affected brains, and has been suggested as a causative factor. Dopaminergic …

Neuroinflammation in Parkinson's disease

EC Hirsch, S Vyas, S Hunot - Parkinsonism & related disorders, 2012 - Elsevier
Both epidemiological and genetic studies support a role of neuroinflammation in the
pathophysiology of Parkinson's disease (PD). Furthermore, post mortem studies confirm the …