Ten unsolved questions about neuroinflammation in Parkinson's disease

EC Hirsch, DG Standaert - Movement Disorders, 2021 - Wiley Online Library
Parkinson's disease is a progressive and debilitating disorder that has so far eluded
attempts to develop disease‐modifying treatment. Both epidemiological and genetic studies …

[HTML][HTML] A systematic review and meta-analysis of inflammatory biomarkers in Parkinson's disease

Y Qu, J Li, Q Qin, D Wang, J Zhao, K An, Z Mao… - npj Parkinson's …, 2023 - nature.com
Neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD), but
controversies persist. Studies reporting concentrations of blood or cerebrospinal fluid (CSF) …

Oxidative stress and neuroinflammation in the story of Parkinson's disease: could targeting these pathways write a good ending?

K Hassanzadeh, A Rahimmi - Journal of cellular physiology, 2019 - Wiley Online Library
Although, current medications for Parkinson's disease can control and relief symptoms of the
disease efficiently, they are unable to either prevent progression of the disease or maintain …

[HTML][HTML] Transforming growth factor β1-mediated anti-inflammation slows progression of midbrain dopaminergic neurodegeneration in Parkinson's disease?

B Spittau - Neural regeneration research, 2015 - journals.lww.com
Parkinson's disease (PD) is characterized by the progressive loss of midbrain dopaminergic
(mDA) neurons and a subsequent decrease in striatal dopamine levels, which cause the …

Strategic selection of neuroinflammatory models in Parkinson's disease: evidence from experimental studies

S Vasant More, H Kumar, IS Kim… - CNS & Neurological …, 2013 - ingentaconnect.com
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic
neurons in the substantia nigra pars compacta (SNpc). Although the exact cause of the …

Novel anti-inflammatory and neuroprotective agents for Parkinson's disease

L Lu, F Li, X Wang - … (Formerly Current Drug Targets-CNS & …, 2010 - ingentaconnect.com
Parkinson's disease (PD) is a type of motor system disorder that results from the progressive
loss of dopaminergic (DAergic) neurons in the substantia nigra (SN) of the midbrain. It is one …

Neuroinflammation and Parkinson's disease

S Przedborski - Handbook of clinical neurology, 2007 - Elsevier
Publisher Summary Parkinson's disease (PD) is the second most frequent
neurodegenerative disorder of the aging brain after Alzheimer's dementia. Its clinical …

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

EC Hirsch, S Hunot - The Lancet Neurology, 2009 - thelancet.com
Parkinson's disease is characterised by a slow and progressive degeneration of
dopaminergic neurons in the substantia nigra. Despite intensive research, the cause of the …

[HTML][HTML] Neuroinflammation and autophagy in Parkinson's disease—novel perspectives

D Minchev, M Kazakova, V Sarafian - International Journal of Molecular …, 2022 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. It is
characterized by the accumulation of α-Synuclein aggregates and the degeneration of …

The role of neuroinflammation in neurodegenerative disorders

J Suescun, S Chandra, MC Schiess - Translational inflammation, 2019 - Elsevier
Neurodegenerative disorders encompass a range of conditions in which neuronal structure
and function are altered affecting the brain and spinal cord [central nervous system (CNS)] …