In recent years it has become widely recognized that histone modification plays a pivotal
role in controlling gene expression and is involved in a wide spectrum of disease regulation …

The dysregulation of gene expression is a critical event involved in all steps of
tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene …

Transcriptional regulation in eukaryotes is a multilevel hierarchical process. It is becoming
clear that higher-order chromatin structure, occurring via modifications of histones in their …

Histone deacetylases (HDACs) deacetylate histones H3 and H4. An imbalance between
histone acetylation and deacetylation can lead to various diseases. HDAC2 is present in the …

Aberrant gene regulation plays an important role in tumor initiation and progression, and the
acetylation of histones is a well understood key component of gene regulation. Histone …

Abstract Purpose: Histone deacetylase inhibitors (HDACi) are actively explored as new-
generation epigenetic drugs but have low efficacy in cancer monotherapy. To reveal new …

Background: Many laboratories have made intensive efforts to develop potent, selective, and
orally bioavailable HDAC inhibitors (HDACIs). Novel HDACIs are being developed with the …

The treatment of tumor cells with HDAC inhibitors (HDACi) induces a range of effects
including apoptosis, cell cycle arrest, differentiation and senescence, modulation of immune …

Histone deacetylases (HDACs) are negative regulators of gene expression and have been
implicated in tumorigenesis and tumor progression. Therefore, HDACs are promising targets …

Histone deacetylases are known to play a central role in the regulation of several cellular
properties intimately interlinked with the development and progression of cancer …